期刊
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
卷 55, 期 1, 页码 -出版社
ASSOC BRAS DIVULG CIENTIFICA
DOI: 10.1590/1414-431X2022e11795
关键词
Exercise intensity; Insulin resistance; Glycemic control; Type 2 diabetes mellitus; Skeletal muscle; Metabolism
资金
- National Council for Scientific and Technological Development (CNPq)
- Coordination for the Improvement of Higher Education Personnel (CAPES) [88881.068515/201401]
- Sao Paulo State Research Foundation (FAPESP) [2018/09868-7, 2018/07283-1, 2019/25892-8]
- FAPESP scholarships [2020/06641-1, 2020/06642-8]
- CAPES scholarship [8888.7598043/2021-00]
- CNPq scholarships [308955/2020-0, 310711/2020-7]
Physical exercise can reduce insulin levels, increase muscle glycogen content, improve exercise tolerance, protect renal and myocardial function, and enhance blood oxygen flow in non-obese type 2 diabetes mellitus.
There is a high incidence of non-obese type 2 diabetes mellitus (non-obese-T2DM) cases, particularly in Asian countries, for which the pathogenesis remains mainly unclear. Interestingly, Goto-Kakizaki (GK) rats spontaneously develop insulin resistance (IR) and non-obese-T2DM, making them a lean diabetes model. Physical exercise is a non-pharmacological therapeutic approach to reduce adipose tissue mass, improving peripheral IR, glycemic control, and quality of life in obese animals or humans with T2DM. In this narrative review, we selected and analyzed the published literature on the effects of physical exercise on the metabolic features associated with non-obese-T2DM. Only randomized controlled trials with regular physical exercise training, freely executed physical activity, or skeletal muscle stimulation protocols in GK rats published after 2008 were included. The results indicated that exercise reduces plasma insulin levels, increases skeletal muscle glycogen content, improves exercise tolerance, protects renal and myocardial function, and enhances blood oxygen flow in GK rats.
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