4.4 Review

Vaginal progesterone compared with intramuscular 17-alpha-hydroxyprogesterone caproate for prevention of recurrent preterm birth in singleton gestations: a systematic review and meta-analysis

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Summary: This study aimed to compare vaginal progesterone with 17-hydroxyprogesterone caproate in preventing recurrent preterm birth in singleton pregnancies with previous spontaneous preterm birth. The results showed that vaginal progesterone did not reduce the risk of recurrent preterm birth by 50% compared to 17-OHPC, but it may lead to increased latency to delivery.

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