Crystal-induced collapsing podocytopathy and light chain proximal tubulopathy in monoclonal gammopathy of renal significance

Review Urology & Nephrology

The Crystalline Nephropathies

Mark A. Perazella et al.

Summary: Crystalline nephropathies are a unique form of kidney disease characterized by the deposition of crystals in the kidneys, leading to kidney injury and inflammation. Common clinical manifestations include abnormal urinalysis, tubulopathies, acute kidney injury, and/or chronic kidney disease.

KIDNEY INTERNATIONAL REPORTS (2021)

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Review Urology & Nephrology

Kidney injury and disease in patients with haematological malignancies

Frank Bridoux et al.

Summary: Patients with haematological cancer are at a higher risk of kidney injury, either as a direct result of the malignancy or due to treatment-related effects. It is common for cancer patients, especially those with haematological malignancies, to experience acute kidney injury (AKI) which can be caused by the underlying blood disorder.

NATURE REVIEWS NEPHROLOGY (2021)

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Review Medicine, General & Internal

Monoclonal Gammopathy of Renal Significance

Nelson Leung et al.

Summary: Monoclonal gammopathy of renal significance is a non-cancerous clonal disorder that produces monoclonal immunoglobulin leading to kidney injury or disease. It is discussed in terms of pathogenesis, evaluation, and management.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Urology & Nephrology

Crystal-Induced Podocytopathy Producing Collapsing Focal Segmental Glomerulosclerosis in Monoclonal Gammopathy of Renal Significance: A Case Report

Anna Buxeda et al.

Summary: This is a rare case of monoclonal gammopathy-associated crystalline podocytopathy causing collapsing FSGS and corneal crystal deposition leading to vision loss. Crystalline podocytopathy should be considered in the differential diagnosis, and careful ultrastructural examination of kidney biopsy specimen is crucial for establishing this diagnosis.

KIDNEY MEDICINE (2021)

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Review Urology & Nephrology