In vivo gain-of-function cDNA library screening for colonization genes in a mouse model of pulmonary metastasis

Summary: The metabolic enzyme ALDOA was identified as a driver of cancer cell motility and metastatic colonization, with AMPK playing an essential role in ALDOA-expressing cells. These findings highlight the previously undescribed roles of the ALDOA-AMPK pathway in tumor progression and adverse patient outcomes in various malignancies.