期刊
SURFACE INNOVATIONS
卷 4, 期 3, 页码 133-140出版社
ICE PUBLISHING
DOI: 10.1680/jsuin.16.00014
关键词
biocompatibility; biodegradable; biointerface
资金
- US National Institutes of Health-National Institute of Biomedical Imaging and Bioengineering [5R21 EB 019118-02]
- US National Institutes of Health-National Heart, Lung, and Blood Institute [1R15 HL129199-01]
- Michigan Initiative for Innovation and Entrepreneurship's Technology Commercialization program
A better understanding of the surface oxide film on biodegradable metals could lead to the design of smarter, surface-responsive biodegradable stents with good biocompatibility and controlled degradation rates at different stages of implantation. In this study, the surface finish of zinc was manipulated through different material processing conditions, including oxidation, electropolishing and anodization. Implant wires with oxide films of varying surface characteristics were degraded in a living organism by using a rodent model to understand their response to a biological endovascular environment. It was found that the degradation rate was mainly dependent on the quality and stability of oxide film. Defects/cracks in the oxide film structure appear to serve as local corrosion sites, and their increased density accelerates the biocorrosion rate.
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