期刊
ENDOCRINE
卷 77, 期 1, 页码 151-159出版社
SPRINGER
DOI: 10.1007/s12020-022-03051-6
关键词
Pituitary neuroendocrine tumours; Non-functioning pituitary adenomas; Corticotroph pituitary adenomas; Adherence junctions; Prognostic markers of pituitary tumours
资金
- Swedish Cancer Society [190157 Fk]
- Swedish government
- Swedish county councils (ALF-agreement)
- University of Oslo (Oslo University Hospital)
This study characterizes the distribution of E- and N-cadherin in different types of clinically non-functioning pituitary neuroendocrine tumors (NF-PitNETs) and links it to the course of the tumors. The results indicate that high levels of N-cadherin and downregulation of membranous E-cadherin are not associated with a more aggressive tumor behavior in these subgroups of NF-PitNETs.
Purpose Clinically non-functioning pituitary neuroendocrine tumours (NF-PitNETs) present a varying degree of aggressiveness, and reliable prognostic markers are lacking. We aimed to characterise the distribution of E- and N-cadherin in corticotroph, PIT1 and null-cell NF-PitNETs, and link it to the course of the tumours. Methods The distribution of E- and N-cadherin was investigated by immunohistochemistry in a retrospective cohort of 30 tumours of the less common NF-PitNETs (corticotroph (N = 18), PIT1 (N = 8) and null-cell PitNETs (N = 4)). Immunoreactive scores (IRS) were compared to previously presented cohorts of gonadotroph NF-PitNETs (N = 105) and corticotroph functioning PitNETs (N = 17). Results We found a low IRS for the extra-cellular domain of E-cadherin (median 0 (IQR 0-0, N = 135)), a medium to high IRS for the intra-cellular domain of E-cadherin (median 6 (IQR 4-9)) and a high IRS for N-cadherin (median 12 (IQR 10.5-12)) throughout the cohort of NF-PitNETs. The corticotroph NF-PitNETs presented a higher IRS for both the extra- and intra-cellular domain of E-cadherin (median 0 (IQR 0-1) and median 9 (IQR 6-12), respectively) than the gonadotroph NF-PitNETs (p < 0.001 for both comparisons). Presence of nuclear E-cadherin was associated with a weaker staining for the intra-cellular domain of E-cadherin (median 4 (IQR 0.5-6) and median 9 (IQR 9-12), for tumours with and without nuclear E-cadherin, respectively), and with a lower rate of re-intervention (p = 0.03). Conclusions Considering our results and the benign course of NF-PitNETs, we suggest that a high N-cadherin and downregulation of membranous E-cadherin are not associated with a more aggressive tumour behaviour in these subgroups of NF-PitNETs.
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