4.7 Article

A highly enantioselective approach towards optically active γ-amino alcohols by tin-catalyzed kinetic resolution of 1,3-amino alcohols

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Summary: A highly enantioselective method for the kinetic resolution of racemic tertiary alcohols has been developed using chiral organotin-catalyzed intermolecular acylation. The process can be carried out under mild reaction conditions and has a broad substrate scope, allowing for the separation of the corresponding products and highly enantioselective recovery of tertiary alcohols with s factors up to >200.

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