Coagulome and the tumor microenvironment: an actionable interplay

Human tumors often trigger a hypercoagulable state that promotes hemostatic complications, including venous thromboembolism. The recent application of systems biology to the study of the coagulome highlighted its link to shaping the tumor microenvironment (TME), both within and outside of the vascular space. Addressing this link provides the opportunity to revisit the significance of biomarkers of hemostasis and assess the communication between vasculature and tumor parenchyma, an important topic considering the advent of immune checkpoint inhibitors and vascular normalization strategies. Understanding how the coagulome and TME influence each other offers exciting new prospects for predicting hemostatic complications and boosting the effectiveness of cancer treatment.

Automated summary

Tumors often cause a hypercoagulable state that promotes blood clotting complications, including venous thromboembolism. Recent research has shown the connection between coagulome and tumor microenvironment, which is important for studying biomarkers and the interaction between blood vessels and tumor parenchyma. Understanding the mutual influence of the coagulome and tumor microenvironment offers exciting prospects for predicting blood clotting complications and improving cancer treatment effectiveness.