4.6 Article

Copper(II) salen-based complexes as potential anticancer agents

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Chemistry, Multidisciplinary

Synthesis and Cytotoxic Activity of Novel Metal Complexes Derived from Methyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoate as Potential CDK8 Kinase Inhibitors

Ahmed Aboelmagd et al.

Summary: A series of new metal complexes were synthesized and tested for their anti-tumor activities on colorectal carcinoma cells and normal cells. Most of the compounds showed significant inhibitory effects on cancer cells while having no impact on normal cells.

ACS OMEGA (2021)

Article Chemistry, Medicinal

Dithiocarbazate-Copper Complexes for Bioimaging and Treatment of Pancreatic Cancer

Yi Gou et al.

Summary: The three fluorescent dithiocarbazate-copper complexes showed significant cytotoxicity against pancreatic cancer cell lines, with complex 3 primarily targeting mitochondria and inducing cell death through mechanisms including ferroptosis. This complex is the first copper complex to demonstrate cellular events consistent with ferroptosis in cancer cells and effectively inhibited the growth of ASPC-1 cells in a mouse xenograft model.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Ethidium bromide interactions with DNA: an exploration of a classic DNA-ligand complex with unbiased molecular dynamics simulations

Rodrigo Galindo-Murillo et al.

Summary: Visualizing double stranded DNA in gels with ethidium bromide has been a basic experimental technique in molecular biology labs for over 40 years. Molecular dynamics simulations of ethidium interaction with different DNA models can reproduce experimental results and provide new insights, demonstrating the capability of modern DNA force fields and optimized simulation codes.

NUCLEIC ACIDS RESEARCH (2021)

Article Chemistry, Inorganic & Nuclear

Synthesis, crystal structures and magnetism of CuIILnIII N2O4-donor coordination compounds involving dicyanamides

Shao-Liang Zhang et al.

Summary: Three new heterometallic Cu-II-Ln(III) complexes have been synthesized and characterized, with two monomers and one cluster structure. Complexes 2(CuTb) and 3(CuDy) exhibit ferromagnetic interactions between the Cu(II) and Tb(III) or Dy(III) ions.

POLYHEDRON (2021)

Article Chemistry, Multidisciplinary

Catechol oxidation promoted by bridging phenoxo moieties in a bis(μ-phenoxo)-bridged dicopper(ii) complex

Debojyoti Mukherjee et al.

Summary: A dinuclear copper(ii) complex has been synthesized and characterized, showing weak ferromagnetic interactions and high catecholase activity. A reaction mechanism has been proposed based on experimental findings.

RSC ADVANCES (2021)

Article Chemistry, Multidisciplinary

A trinuclear Zn(II) Schiff base azido compound: synthesis, structure and exploration of antimicrobial activity

Mrinmoy Ghosh et al.

Summary: In this study, a novel trinuclear zinc (II) complex was synthesized and its antibacterial and antibiofilm activities were evaluated. The complex showed potential antibacterial activity against various bacterial strains, with maximum sensitivity against Pseudomonas aeruginosa. The zinc compound exhibited inhibition of DNA synthesis and biofilm formation in Pseudomonas aeruginosa, suggesting its potential as a candidate for developing antibacterial drugs.

NEW JOURNAL OF CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Regulation of π•••π stacking interactions between triimidazole luminophores and comprehensive emission quenching by coordination to Cu(II)

Elena Melnic et al.

Summary: Eight Cu(ii) coordination compounds with cyclic triimidazole ligands and its derivatives were reported. These compounds consist of neutral Cu(ii) discrete complexes or coordination polymers comprising luminophore triimidazole molecules and charge-compensated anions. The aggregation-induced emission demonstrated by pure luminophores was nearly quenched in the reported Cu(ii) coordination compounds in the solid state.

NEW JOURNAL OF CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Synthesis and theoretical calculations of metal-antibiotic chelation with thiamphenicol: in vitro DNA and HSA binding, molecular docking, and cytotoxicity studies

Abeer A. Sharfalddin et al.

Summary: Metal complexes of Thiamphenicol (TM) with Zn(ii), Cu(ii), Ni(ii), Co(ii), and Fe(ii) were synthesized and characterized using various analytical techniques. The complexes showed antimicrobial and anticancer activities, with DNA intercalation binding mode and high binding affinity with protein (HSA). Molecular docking was used to explain the biological inhibition mechanism of certain metal complexes.

NEW JOURNAL OF CHEMISTRY (2021)

Article Chemistry, Inorganic & Nuclear

Influence of anchoring moieties on new benzimidazole-based Schiff base copper(ii) complexes towards estrogen dependent breast cancer cells

Anup Paul et al.

Summary: The two newly synthesized copper(II) compounds exhibit significant in vitro cytotoxic effects, particularly showing pronounced inhibitory effects on the proliferation of the breast cancer cell line MCF-7. Through various biological studies, the effective antiproliferative mechanism of compound 1 on breast cancer cells has been confirmed.

DALTON TRANSACTIONS (2021)

Article Chemistry, Inorganic & Nuclear

Phenoxo-bridged dinuclear mixed valence cobalt(III/II) complexes with reduced Schiff base ligands: synthesis, characterization, band gap measurements and fabrication of Schottky barrier diodes

Abhisek Banerjee et al.

Summary: Two homometallic class-I dinuclear mixed valence cobalt complexes have been synthesized and characterized, showing good electrical conductivity as semiconductors. Band gap measurements were used to determine the band structure, while SCLC theory was employed to analyze charge transport parameters.

DALTON TRANSACTIONS (2021)

Article Chemistry, Multidisciplinary

Tuning the coordination behavior of an unexplored asymmetric multidentate ligand for developing diverse heterometallic architectures with luminescent and magnetic properties

Xue-Qin Song et al.

Summary: By tuning the coordination behavior of a new asymmetric multidentate ligand, three types of heterometallic compounds were successfully developed and structurally analyzed. Luminescence studies indicated that the Zn-II-containing chromophore is an effective antenna and exhibits less concentration quenching compared to its Ni-II analogues.

CRYSTENGCOMM (2021)

Article Multidisciplinary Sciences

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

Ana Rakita et al.

SCIENTIFIC REPORTS (2020)

Article Chemistry, Inorganic & Nuclear

Investigation on catecholase activity of salen Co(III) octahedral complexes

Nithya Mohan et al.

POLYHEDRON (2019)

Article Chemistry, Multidisciplinary

Self-Assembled Copper Amino Acid Nanoparticles for in Situ Glutathione AND H2O2 Sequentially Triggered Chemodynamic Therapy

Baojin Ma et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Chemistry, Multidisciplinary

Copper( II) complexes based on tripodal pyridyl amine derivatives as efficient anticancer agents

Salah S. Massoud et al.

NEW JOURNAL OF CHEMISTRY (2019)

Article Chemistry, Medicinal

High anticancer potency on tumor cells of dehydroabietylamine Schiff-base derivatives and a copper(II) complex

Fengyi Zhao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Inorganic & Nuclear

Half-Sandwich Iridium(III) and Ruthenium(II) Complexes Containing PP-Chelating Ligands

JuanJuan Li et al.

INORGANIC CHEMISTRY (2018)

Article Multidisciplinary Sciences

In vitro cytotoxicity activity of novel Schiff base ligand-lanthanide complexes

Kavitha Andiappan et al.

SCIENTIFIC REPORTS (2018)

Article Chemistry, Inorganic & Nuclear

Half-Sandwich Iridium and Ruthenium Complexes: Effective Tracking in Cells and Anticancer Studies

JuanJuan Li et al.

INORGANIC CHEMISTRY (2018)

Article Chemistry, Medicinal

Half-sandwich Schiff-base Ir(III) complexes as anticancer agents

Ze-dong Mou et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells

Narayana Nagesh et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2015)

Article Biochemistry & Molecular Biology

DNA interaction and efficient antimicrobial activities of 4N chelating metal complexes

S. Packianathan et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2015)

Review Chemistry, Multidisciplinary

Advances in Copper Complexes as Anticancer Agents

Carlo Santini et al.

CHEMICAL REVIEWS (2014)

Article Chemistry, Inorganic & Nuclear

Chiral Single-Chain Magnet: Helically Stacked [MnIII2CuII] Triangles

Takuya Shiga et al.

INORGANIC CHEMISTRY (2014)

Review Chemistry, Multidisciplinary

The Cation-π Interaction

Dennis A. Dougherty

ACCOUNTS OF CHEMICAL RESEARCH (2013)

Review Chemistry, Multidisciplinary

Cation-π Interaction: Its Role and Relevance in Chemistry, Biology, and Material Science

A. Subha Mahadevi et al.

CHEMICAL REVIEWS (2013)

Article Chemistry, Inorganic & Nuclear

Fluorescence-Based Nitric Oxide Sensing by Cu(II) Complexes That Can Be Trapped in Living Cells

Lindsey E. McQuade et al.

INORGANIC CHEMISTRY (2010)

Article Nutrition & Dietetics

Cation-π interactions involving aromatic amino acids

Dennis A. Dougherty

JOURNAL OF NUTRITION (2007)

Article Chemistry, Multidisciplinary

Changing selectivity of DNA oxidation from deoxyribose to guanine by ligand design and a new binuclear copper complex

L Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Article Biochemistry & Molecular Biology

The interaction of native DNA with iron(III)-N,N′-ethylene-bis(salicylideneiminato)-chloride

A Silvestri et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2004)