期刊
SPRINGERPLUS
卷 5, 期 -, 页码 -出版社
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1186/s40064-016-2145-1
关键词
Brine shrimp lethality; Artemia salina; Methanol extracts; Bioactivity
The brine shrimp (Artemia salina) bioassay was used to screen 211 methanol extracts from 128 species of Pacific Northwest plants in search of general cytotoxic activity. Strong toxicity (LC50 < 100 mu g/ml) was found for 17 extracts from 13 species, with highest activity observed for Angelica arguta roots at < 10 mu g/ml. Notably, four species of cedar trees and one of juniper in the family Cupressaceae dominated this group with LC50 for heartwood extracts ranging from 15 to 89 mu g/ml. Moderate toxicity (LC50 100-500 mu g/ml) was found in 38 extracts from 27 species, while weak toxicity (LC50 500-1000 mu g/ml) was detected for 17 extracts in 16 species. There were 139 extracts from 99 species that were non-toxic (LC50 > 1000 mu g/ml). Our subsequent studies of conifer heartwoods with strong activity confirm the assay's value for identifying new investigational leads for materials with insecticidal and fungicidal activity.
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