Analysis of sugars and sweeteners via terahertz time-domain spectroscopy

A THz-TDS spectrometer (terahertz time-domain spectroscopy) with ASOPS technology (asynchronous optical sampling) was employed in this study, aiming to explore the potential of the technique and to develop analytical applications for the identification of some saccharides. Analytical curves with linear responses were obtained in the saccharide concentration range from 1.7 to 11.7 (w/w). The characteristic peaks used for each sugar for univariate calibrations were fructose (1.704 THz), sucrose (1.827 THz), glucose (1.435 THz), lactose (1.373 THz), saccharin (2.664 THz), and sucralose (2.219 THz). Limits of detection around 1.0% (m/m) were obtained. Gaussian peak fitting was also employed as a tool to aid in the identification of saccharide components in mixtures and it was observed that the region between 0.5 and 2.0 THz is more adequate for such analysis since scattering is less evident. It was observed that in a mixture of sucrose, glucose and lactose (5% or 10% (m/m) each) in the range of 1.31 to 1.51 THz some sub-peaks of pure lactose and glucose can be identified.

Automated summary

In this study, a THz-TDS spectrometer with ASOPS technology was used to explore the potential of this technique for the identification of saccharides. Linear analytical curves were obtained in the concentration range of 1.7 to 11.7 (w/w). Gaussian peak fitting was employed to aid in the identification of saccharide components in mixtures. The results showed that the region between 0.5 and 2.0 THz is more suitable for analysis and scattering is less evident within this range.