Gold nanoparticles-oxidized multi-walled carbon nanotubes as electrochemiluminescence immunosensors

Oxidized multi-walled carbon nanotube/nano-gold (AuNP-ox-MWCNT) composites with strong electrochemiluminescence (ECL) activity were applied to construct a new ECL immunosensor for the detection of carcinoembryonic antigen (CEA). The immunosensor showed a linear response range of 10-100 ng mL(-1) and detection limit of 0.76 ng mL(-1) (at a signal-to-noise ratio of 3). The as-developed immunosensor exhibited several advantages, including being simple to fabricate and being label free. The results indicated that ox-MWCNTs as a luminescent material have great application potential in analysis.

Automated summary

An ECL immunosensor for the detection of carcinoembryonic antigen (CEA) was constructed using oxidized multi-walled carbon nanotube/nano-gold (AuNP-ox-MWCNT) composites with strong electrochemiluminescence (ECL) activity. The immunosensor showed a wide linear response range and a low detection limit, and was simple to fabricate and label-free.