期刊
RSC CHEMICAL BIOLOGY
卷 3, 期 7, 页码 815-829出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cb00246e
关键词
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资金
- National Key R&D Program of China [2020YFA0908100]
- National Natural Science Foundation of China [21534006, 21925102, 21991132, 81991505, 92056118]
- Beijing National Laboratory for Molecular Sciences [BNLMS-CXXM-202006]
- Bayer Investigator Award
- Boya Postdoc Fellowship from Peking University
- China Postdoctoral Science Foundation [2020TQ0005]
This article reviews recent progress in the application of cyclic or multicyclic peptides and proteins to the development of artificial peptides and proteins. In addition to simple cyclic forms, various macrocycle variants, such as knots and links, have been developed. The chemical tools and synthetic strategies for the biological synthesis of these macrocycles are summarized, demonstrating its potential as a powerful alternative to chemical synthesis. Furthermore, the application of these macrocycles to therapeutic peptides/proteins has led to significant improvements in pharmaceutical performances.
Living organisms have evolved cyclic or multicyclic peptides and proteins with enhanced stability and high bioactivity superior to their linear counterparts for diverse purposes. Herein, we review recent progress in applying this concept to artificial peptides and proteins to exploit the functional benefits of these macrocycles. Not only have simple cyclic forms been prepared, numerous macrocycle variants, such as knots and links, have also been developed. The chemical tools and synthetic strategies are summarized for the biological synthesis of these macrocycles, demonstrating it as a powerful alternative to chemical synthesis. Its further application to therapeutic peptides/proteins has led to biomedicines with profoundly improved pharmaceutical performances. Finally, we present our perspectives on the field and its future developments.
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