A multifunctional nanoplatform delivering carbon monoxide and a cysteine protease inhibitor to mitochondria under NIR light shows enhanced synergistic anticancer efficacy

Article Engineering, Biomedical

Tumor Microenvironment-AND Near-Infrared Light-Activated Coordination Polymer Nanoprodrug for On-Demand CO-Sensitized Synergistic Cancer Therapy

Panpan Sun et al.

Summary: A novel CO prodrug system has been developed, which releases sufficient quantities of CO and radicals to destruct cancer cells through a coordination assembled strategy, while maintaining non-toxicity to surrounding normal tissues.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

A Multichannel Ca2+ Nanomodulator for Multilevel Mitochondrial Destruction-Mediated Cancer Therapy

Pan Zheng et al.

Summary: This study presents a multichannel calcium ion nanomodulator that enhances mitochondrial dysfunction in cancer therapy, resulting in effective tumor inhibition. After systemic administration, the nanomodulator selectively accumulates in tumor tissues, providing targeted treatment.

ADVANCED MATERIALS (2021)

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Review Biochemistry & Molecular Biology

The Tumor Proteolytic Landscape: A Challenging Frontier in Cancer Diagnosis and Therapy

Matej Vizovisek et al.

Summary: In recent years, dysregulation of proteases in cancer has been identified as an important hallmark, leading to community-wide efforts to explore this proteolytic landscape. Advancements in technology have enabled sensitive detection of proteases with potential for clinical translation. Despite the high cost of these technologies, emerging protease sensors hold promise for comprehensive exploration of tumor proteolytic landscape.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death

Pan Zheng et al.

Summary: This study developed an acid-sensitive nanoparticle ((CaCUR)-Ca-PEG) that induces mitochondrial Ca2+ overload and acts as an ICD inducer in improved cancer therapy. Combination with ultrasound (US) enhances the ICD effect, showing promising therapeutic and diagnostic properties.

NANO LETTERS (2021)

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Review Physics, Applied

Smart transformable nanoparticles for enhanced tumor theranostics

Jinjin Chen et al.

Summary: The physical morphologies of nanoparticles significantly influence their biological behaviors, and smart transformable nanomaterials show great potential in advanced tumor theranostics.

APPLIED PHYSICS REVIEWS (2021)

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Article Nanoscience & Nanotechnology

Tumor Microenvironment-Activated Nanoparticles Loaded with an Iron-Carbonyl Complex for Chemodynamic Immunotherapy of Lung Metastasis of Melanoma In Vivo

Tianli Zhai et al.

Summary: This work describes the construction of a nanoplatform loaded with an iron-carbonyl complex, which showed excellent efficacy against lung metastasis of melanoma through chemodynamic therapy and immunogenic cell death-induced immunotherapy. The nanomaterials released CO and generated ferrous iron to cause tumor cell death via mitochondrial damage and oxidative stress, while also inducing immunotherapy to further enhance therapeutic effects. This self-assembling nanoplatform utilized simple building blocks to target tumors and has the potential for future clinical applications in treating various types of tumors.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Interfacially Engineered ZnxMn1-xS@Polydopamine Hollow Nanospheres for Glutathione Depleting Photothermally Enhanced Chemodynamic Therapy

Juan Ruan et al.

Summary: The Fenton-like reactions driven by manganese-based nanostructures can be tuned by a controllable release of Mn ions, leading to specific toxicity to cancer cells. The ZnxMn1-xS@PDA composites show potential for synergistic chemodynamic and photothermal therapies for cancer treatment.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Trifluoromethyl substitution enhances photoinduced activity against breast cancer cells but reduces ligand exchange in Ru(ii) complex

Austin P. Lanquist et al.

Summary: A series of five ruthenium complexes containing triphenyl phosphine groups were synthesized and characterized, with one complex showing enhanced cytotoxicity upon irradiation with blue light due to apoptosis mechanism. These findings highlight the enhancement of photochemotherapy by -CF3 groups and provide insight for future design of photocages for photochemotherapeutic drug delivery.

CHEMICAL SCIENCE (2021)

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Article Materials Science, Biomaterials

Mitochondria-targeted carbon monoxide delivery combined with singlet oxygen production from a single nanoplatform under 808 nm light irradiation for synergistic anticancer therapy

Qi Tang et al.

Summary: A multifunctional nanoplatform was developed for mitochondria-targeted carbon monoxide (CO) delivery combined with photodynamic therapy, showing high lethality against cancer cells and good dark biocompatibility with normal cells expressing low H2O2 levels. This work may offer new insights into efficient cancer treatment by combining CO-based gas therapy with traditional PDT.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

Mitochondria targeted nanoparticles to generate oxygen and responsive-release of carbon monoxide for enhanced photogas therapy of cancer

Hao Ren et al.

Summary: The study developed human serum albumin nanoparticles combined with manganese dioxide to deliver a CO donor and photosensitizer for a synergistic therapy combining CO gas therapy and phototherapy. By catalyzing hydrogen peroxide to produce oxygen, the nanoparticles enhanced photodynamic therapy and triggered CO release for enhanced gas therapy. The strategy provides a novel approach for cancer treatment by combining phototherapy and CO gas therapy with oxygen generating and thermal-responsive CO release.

BIOMATERIALS SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Identification of a PAI-1-binding site within an intrinsically disordered region of vitronectin

Yuzhuo Chu et al.

PROTEIN SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Visible Light-Gated Organocatalysis Using a RuII-Photocage

Jose A. Gonzalez-Delgado et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

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Review Multidisciplinary Sciences

Strategies for engineering advanced nanomedicines for gas therapy of cancer

Yingshuai Wang et al.

NATIONAL SCIENCE REVIEW (2020)

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Article Multidisciplinary Sciences

A multistage assembly/disassembly strategy for tumor-targeted CO delivery

Jin Meng et al.

SCIENCE ADVANCES (2020)

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Article Chemistry, Multidisciplinary

Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition

Da Zhang et al.

ACS NANO (2020)

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Review Engineering, Biomedical

Harnessing carbon monoxide-releasing platforms for cancer therapy

Yang Zhou et al.

BIOMATERIALS (2020)

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Article Materials Science, Biomaterials

A nanometer-sized protease inhibitor for precise cancer diagnosis and treatment

Ping Hu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Engineering, Biomedical

On-demand CO release for amplification of chemotherapy by MOF functionalized magnetic carbon nanoparticles with NIR irradiation

Jizong Yao et al.

BIOMATERIALS (2019)

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Review Biochemistry & Molecular Biology

Proteases: History, discovery, and roles in health and disease

Judith S. Bond

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

Thermal-Responsive Carbon Monoxide (CO) Delivery Expedites Metabolic Exhaustion of Cancer Cells toward Reversal of Chemotherapy Resistance

Yongjuan Li et al.

ACS CENTRAL SCIENCE (2019)

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Article Biochemistry & Molecular Biology

Light-activated ruthenium (II)-bicalutamide prodrugs for prostate cancer

Jian Zhao et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2019)

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Article Biotechnology & Applied Microbiology

Programmed ROS/CO-releasing nanomedicine for synergetic chemodynamic-gas therapy of cancer

Bin Zhao et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model

Vincent H. S. van Rixel et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Chemistry, Multidisciplinary

A nanoscale metal-organic framework for combined photodynamic and starvation therapy in treating breast tumors

Qun Guan et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Ru(II) polypyridyl complexes as photocages for bioactive compounds containing nitriles and aromatic heterocycles

Ao Li et al.

CHEMICAL COMMUNICATIONS (2018)

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Article Chemistry, Multidisciplinary

New Ru(II) photocages operative with near-IR light: new platform for drug delivery in the PDT window

Malik H. Al-Afyouni et al.

CHEMICAL SCIENCE (2018)

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Article Chemistry, Multidisciplinary

PDT-Driven Highly Efficient Intracellular Delivery and Controlled Release of CO in Combination with Sufficient Singlet Oxygen Production for Synergistic Anticancer Therapy

Lihuang Wu et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Review Chemistry, Inorganic & Nuclear

Metal complex strategies for photo-uncaging the small molecule bioregulators nitric oxide and carbon monoxide

Peter C. Ford

COORDINATION CHEMISTRY REVIEWS (2018)

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Article Chemistry, Multidisciplinary

Upconversion Nanocarriers Encapsulated with Photoactivatable Ru Complexes for Near-Infrared Light-Regulated Enzyme Activity

Zhijun Chen et al.

SMALL (2017)

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Article Chemistry, Multidisciplinary

A Red-Light-Activated Ruthenium-Caged NAMPT Inhibitor Remains Phototoxic in Hypoxic Cancer Cells

Lucien N. Lameijer et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Article Chemistry, Multidisciplinary

Photoactivation of Anticancer Ru Complexes in Deep Tissue: How Deep Can We Go?

Wen Sun et al.

CHEMISTRY-A EUROPEAN JOURNAL (2017)

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Article Chemistry, Analytical

Allyl Fluorescein Ethers as Promising Fluorescent Probes for Carbon Monoxide Imaging in Living Cells

Shumin Feng et al.

ANALYTICAL CHEMISTRY (2017)

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Article Chemistry, Multidisciplinary

Ruthenium nitrosyl functionalized graphene quantum dots as an efficient nanoplatform for NIR-light-controlled and mitochondria-targeted delivery of nitric oxide combined with photothermal therapy

Min Guo et al.

CHEMICAL COMMUNICATIONS (2017)

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Review Medicine, Research & Experimental

Role of protease and protease inhibitors in cancer pathogenesis and treatment

Ali Eatemadi et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Review Biotechnology & Applied Microbiology

Gasotransmitters in cancer: from pathophysiology to experimental therapy

Csaba Szabo

NATURE REVIEWS DRUG DISCOVERY (2016)

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Article Chemistry, Multidisciplinary

NIR-Responsive On-Demand Release of CO from Metal Carbonyl-Caged Graphene Oxide Nanomedicine

Qianjun He et al.

ADVANCED MATERIALS (2015)

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Article Chemistry, Physical

Rapid Eradication of Human Breast Cancer Cells through Trackable Light-Triggered CO Delivery by Mesoporous Silica Nanoparticles Packed with a Designed photoCORM

Indranil Chakraborty et al.

CHEMISTRY OF MATERIALS (2015)

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Review Oncology

Intracellular signaling by cathepsin X: Molecular mechanisms and diagnostic and therapeutic opportunities in cancer

Janko Kos et al.

SEMINARS IN CANCER BIOLOGY (2015)

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Article Chemistry, Multidisciplinary

Near infrared photolysis of a Ru polypyridyl complex by upconverting nanoparticles

E. Ruggiero et al.

CHEMICAL COMMUNICATIONS (2014)

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Article Chemistry, Medicinal

Inhibition of Cathepsin Activity in a Cell-Based Assay by a Light-Activated Ruthenium Compound

Tomasz Respondek et al.

CHEMMEDCHEM (2014)

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Article Chemistry, Inorganic & Nuclear

Ruthenium Tris(2-pyridylmethyl)amine as an Effective Photocaging Group for Nitriles

Rajgopal Sharma et al.

INORGANIC CHEMISTRY (2014)

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Article Oncology

Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth

Barbara Wegiel et al.

CANCER RESEARCH (2013)

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Article Chemistry, Physical

Nitrene-functionalized ruthenium nanoparticles

Xiongwu Kang et al.

JOURNAL OF MATERIALS CHEMISTRY (2012)

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Article Chemistry, Inorganic & Nuclear

[Ru(bpy)2(5-cyanouracil)2]2+ as a Potential Light-Activated Dual-Action Therapeutic Agent

Robert N. Garner et al.

INORGANIC CHEMISTRY (2011)

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Article Chemistry, Multidisciplinary

Light Activation of a Cysteine Protease Inhibitor: Caging of a Peptidomimetic Nitrile with RuII(bpy)2

Tomasz Respondek et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Biotechnology & Applied Microbiology

Lost in migration

George S. Mack et al.

NATURE BIOTECHNOLOGY (2010)

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A multifunctional nanoplatform delivering carbon monoxide and a cysteine protease inhibitor to mitochondria under NIR light shows enhanced synergistic anticancer efficacy

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