期刊
NANOSCALE
卷 14, 期 25, 页码 9097-9103出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2nr01122k
关键词
-
类别
资金
- National Nature Science Foundation of China [21571062]
- Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning
- Fundamental Research Funds for the Central Universities [222201717003]
This study introduces a novel multifunctional nanoplatform capable of mitochondria-targeted co-delivery of a cysteine protease inhibitor and carbon monoxide (CO). It demonstrates significant anticancer efficacy both in vitro and in vivo, as well as good biocompatibility. The co-delivery strategy may provide new insights into combined therapies for cancer treatment.
Photoactivated chemotherapy has attracted widespread attention due to its ability to circumvent the shortcomings of hypoxia in tumor tissues compared with traditional photodynamic therapy. In this work, novel multifunctional nanoplatform (1), Ru-inhibitor@TPPMnCO@N-GQDs, was designed and prepared, which was capable of mitochondria-targeted co-delivery of the cysteine protease inhibitor and carbon monoxide (CO) stimulated with an 808 nm near infrared (NIR) laser. Nanoplatform (1) was prepared by covalent attachment of a mitochondria-targeted CO donor (TPPMnCO) and a Ru(ii)-caged cysteine protease inhibitor (Ru-inhibitor) on the surface of fluorescent N-doped graphene quantum dots (N-GQDs). Nanoplatform (1) preferentially accumulated in the mitochondria of cancer cells and instantly delivered CO and the cysteine protease inhibitor upon 808 nm NIR light irradiation, thus damaging mitochondria and leading to significant in vitro and in vivo anticancer efficacy. In addition, nanoplatform (1) has good biocompatibility and did not exert any toxic side effects on mice during the period of treatment. The targeted subcellular mitochondrial co-delivery of CO and the cysteine protease inhibitor may provide new insights into CO and enzyme inhibitor combined therapies for cancer treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据