期刊
SPRINGERPLUS
卷 5, 期 -, 页码 -出版社
SPRINGER INT PUBL AG
DOI: 10.1186/s40064-016-2607-5
关键词
Lung adenocarcinoma; Histologic classification; ALK status
资金
- National Natural Science Foundation of China [81201692]
- Shanghai Municipal Science and Technology Commission Research Project [16431903200]
- Wu Jie Ping Medical Foundation [320.6750.13350]
- Shanghai Chest Hospital Science and Technology Development Fund [2014YZDC10600]
- Key Project of Shanghai Health and Family Planning Commission [201540365]
Purpose: This study aimed to determine the relationship between ALK status and lung adenocarcinoma subtypes, according to the IALSC/ATS/ERS classification in Chinese patients. Methods: A reclassification of 2299 surgically resected lung adenocarcinomas was performed, and ALK status was detected by immunohistochemistry (Ventana Medical Systems) in Shanghai Chest Hospital. Results: ALK rearrangements were identified in 93 of 2299 tumors (4.0 %). The ALK rearrangements frequencies were: 14.8 % (16/108), 10.3 % (20/195), 7.6 % (13/170), 2.8 % (29/1035), 2.5 % (3/119), 2.0 % (11/539), 0.9 % (1/114), and 0 % (0/19) for variants of invasive adenocarcinoma, solid predominant, micropapillary predominant, acinar predominant, minimally invasive adenocarcinoma, papillary predominant, lepidic predominant, and adenocarcinoma in situ, respectively. Conclusions: We reported significant discrepancies of ALK status in lung adenocarcinoma subtypes in Chinese patients.
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