期刊
JOURNAL OF ALZHEIMERS DISEASE REPORTS
卷 6, 期 1, 页码 297-305出版社
IOS PRESS
DOI: 10.3233/ADR-220020
关键词
COVID-19 pandemic; general practices; Germany; mild cognitive disorder; post-COVID
This retrospective cohort study investigates the association between COVID-19 diagnosis and subsequent mild cognitive disorder (MCD) compared to acute upper respiratory infections (AURI) using data from German general practices. The study finds that the incidence of MCD is higher in COVID-19 patients, especially among younger individuals. Referral to a specialist is recommended when cognitive disorder is suspected.
Background: Little is known about the impact of COVID-19 on mild cognitive disorder. Objective: The aim of this retrospective cohort study was to investigate whether COVID-19 diagnosis is associated with subsequent mild cognitive disorder (MCD) compared to acute upper respiratory infections (AURI). Methods: This retrospective cohort study used data from the Disease Analyzer database (IQVIA) and included 67,046 patients with first-time symptomatic or asymptomatic COVID-19 diagnoses in 1,172 general practices in Germany between March 2020 and September 2021. Diagnoses were based on ICD-10 codes. Patients diagnosed with AURI were matched to 67,046 patients with COVID-19 using propensity scores based on sex, age, index month, and comorbidities. The index date was the diagnosis date for either COVID-19 or AURI. Associations between the COVID-19 and MCD were studied using conditional Poisson regression models. Results: The incidence ofMCDwas 7.6 cases per 1,000 person-years in the COVID-19 group and 5.1 cases per 1,000 personyears in the AURI group (IRR = 1.49, 95% CI = 1.22-1.82). The incidence rate ratio decreased strongly with increasing age from 10.08 (95% CI = 4.00-24.42) in the age group <= 50 to 1.03 (95% CI = 0.81-1.31) in the age group > 70. In addition, the association between COVID-19 and MCD was significant in women (IRR: 1.70, 95% CI: 1.34-2.16) but not in men (IRR: 1.08, 95% CI: 0.75-1.56). Conclusion: The incidence of MCD was low but significantly higher in COVID-19 than in AURI patients, especially among younger patients. If a cognitive disorder is suspected, referral to a specialist is recommended.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据