期刊
JOURNAL OF CANCER
卷 13, 期 9, 页码 2757-2767出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.73143
关键词
Prostate cancer stem cell; CRPC; Bone microenvironment; Metastasis
类别
资金
- Doctoral Fund of Jining No. 1 People's Hospital [2022-BS-002]
- National Natural Science Foundation of China [81803097]
- Natural Science Foundation of Shandong Province [ZR2017QH005]
Prostate cancer is a common cancer that poses a serious threat with bone metastasis and drug resistance. The theoretical model of cancer stem cells explains the characteristics and challenges of cancer. Targeting cancer stem cells might be more effective in overcoming drug resistance and metastasis.
Prostate cancer (PCa) is one of the most common cancers with increasing rates of incidence. Bone metastasis and drug resistance are the most serious threat faced by patients following a delayed diagnosis of cancer, which might lead to treatment failure and death. The theoretical model of cancer stem cells (CSCs) explains the diverse molecular characteristics of cancer as well as its relapse, metastasis and drug resistance. Prostate cancer involves heterogeneous cells community, including prostate cancer stem cells as an important component. These subtypes of cancer cells are usually monoclonal, expressing specific biomarkers and exhibiting self-renewal and differentiation capacity. Therefore, therapies that target CSCs might be more effective in overcome drug resistance and metastasis. Thus, anti-CSCs therapies differ from the traditional anti-proliferative approach. We focus here on reviewing the effects of prostate CSCs on bone metastasis and resistance to traditional treatment in PCa, and report new clinical strategies that address CSC-based tumorigenesis.
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