期刊
ORGANIC CHEMISTRY FRONTIERS
卷 9, 期 14, 页码 3876-3881出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo00462c
关键词
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资金
- Natural Science Foundation of China [22171197]
- Major Basic Research Project of the Natural Science Foundation of Jiangsu Higher Education Institutions [21KJA150002]
- National Local Joint Engineering Laboratory to Functional Adsorption Material Technology for Environmental Protection [SDGC2121]
- PAPD Project
- Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University
A Ni(ii)-catalyzed para-carboxylation of phenol derivatives assisted by 10-phenanthroline has been reported. The reaction shows good compatibility and selectivity with a wide range of substituted phenols. Mechanistic studies reveal that the coordination of Ni(ii) with the hydroxyl group of phenol enhances the activity of the hydroxyl group-bound benzene ring, leading to high para-selectivity.
1,10-Phenanthroline-assisted, Ni(ii)-catalyzed para-carboxylation of phenol derivatives is reported. A wide variety of substituted phenols are compatible with this reaction and led to para-carboxylated products in moderate to good yields. Impressively, various bioactive compounds are selectively carboxylated, and several bioactive molecules, including methyl syringate, methyl gallate, and dimethyl gallate, could also be directly carboxylated in one step. Mechanistic studies show that the coordination of Ni(ii) with the hydroxyl group of phenol enhances the activity of hydroxyl group-bound benzene ring, leading to high para-selectivity, as influenced by the nickel catalyst and ligand steric hindrance.
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