期刊
MATTER
卷 5, 期 6, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.matt.2022.03.001
关键词
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资金
- American Cancer Society [RSG-18-133-01-CDD]
- Goldman Sachs Foundation [162509]
- Bio-X Interdisciplinary Initiatives Seed Grant
- National Cancer Institute of the National Institutes of Health [F32CA247352]
- National Science Foundation Graduate Research Fellowship
- Gabilan Fellowship of the Stanford Graduate Fellowship in Science and Engineering
Liposomal hydrogels, created using lipid nanotechnology and supramolecular self-assembly, offer a highly modular platform for precise control of multi-protein drug release. This system enables synchronized, sustained, and localized release of proteins in vivo, potentially revolutionizing tissue and immuno-engineering.
Directing biological functions is at the heart of next-generation biomedical initiatives in tissue and immuno-engineering. However, the ambitious goal of engineering complex biological networks requires the ability to precisely perturb specific signaling pathways at distinct times and places. Using lipid nanotechnology and the principles of supramolecular self-assembly, we developed an injectable liposomal nanocomposite hydrogel platform to precisely control the release of multiple protein drugs. By integrating modular lipid nanotechnology into a hydrogel, we introduced multiple mechanisms of release based on liposome surface chemistry. To validate the utility of this system for multi-protein delivery, we demonstrated synchronized, sustained, and localized release of immunoglobulin G (IgG) antibody and interleukin-12 (IL-1 2) cytokine in vivo, despite the significant size differences between these two proteins. Overall, liposomal hydrogels are a highly modular platform technology with the ability to mediate orthogonal modes of protein release and the potential to precisely coordinate biological cues both in vitro and in vivo.
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