期刊
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
卷 118, 期 6, 页码 1134-1140出版社
ARQUIVOS BRASILEIROS CARDIOLOGIA
DOI: 10.36660/abc.20201383
关键词
LncRNAs; enzymes; Enzyme Inhibitors; inhibitors; Atherosclerosis; Cardiovascular diseases; Endothelial Cells; VLDL lipoproteins; RNA interference
This review summarizes the recent progress of LncRNAs in the development of atherosclerosis, highlighting their diverse regulatory mechanisms at the transcriptional and post-transcriptional levels, and provides insights into their potential as therapeutic targets or biomarkers for atherosclerosis treatment.
Atherosclerosis is the most common cause of cardiovascular disease globally, associated with a high incidence of clinical events. Accumulating evidence has elucidated that long non-coding RNAs (LncRNAs) as a novel class of transcripts with critical roles in the pathophysiological processes of atherosclerosis. In this review, we summarize the recent progress of LncRNAs in the development of atherosclerosis. We mainly describe the diverse regulatory mechanisms of LncRNAs at the transcriptional and post-transcriptional levels. This study may provide helpful insights about LncRNAs as therapeutic targets or biomarkers for atherosclerosis treatment.
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