期刊
MEDICAL ONCOLOGY
卷 39, 期 9, 页码 -出版社
HUMANA PRESS INC
DOI: 10.1007/s12032-022-01710-2
关键词
Cancer; Long non-coding RNAs; Hedgehog signaling pathway; Tumorigenesis
类别
资金
- Student Research Committee, Kerman University of Medical Sciences (KMU) [400000346]
This review explores the crosstalk between long non-coding RNAs (lncRNAs) and the Hedgehog (Hh) pathway in carcinogenesis, outlining the role of Hh-related lncRNAs in tumor progression and their potential for clinical diagnosis, prognosis, and therapy.
Hedgehog (Hh) is a conserved signaling pathway that is involved in embryo development as well as adult tissue maintenance and repair in invertebrates and vertebrates. Abnormal activation of this pathway in various types of malignant drug- and apoptosis-resistant tumors has made it a therapeutic target against tumorigenesis. Thus, understanding the molecular mechanisms that promote the activation or inhibition of this pathway is critical. Long non-coding RNAs (lncRNAs), a subclass of non-coding RNAs with a length of > 200 nt, affect the expression of Hh signaling components via a variety of transcriptional and post-transcriptional processes. This review focuses on the crosstalk between lncRNAs and the Hh pathway in carcinogenesis, outlines the broad role of Hh-related lncRNAs in tumor progression, and illustrates their clinical diagnostic, prognostic, and therapeutic potential in tumors.
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