K2S2O8-promoted rearrangement of nitrones for the synthesis of benzo[d]oxazoles

An efficient route for the synthesis of valuable benzoxazoles has been developed through self-oxidative cyclization with N-O bond cleavage. Readily available nitrones were used as the starting material under simple metal-free reaction conditions. Various functional groups are compatible with this green protocol which can be carried out in one pot easily.

Automated summary

An efficient route for the synthesis of valuable benzoxazoles has been developed through self-oxidative cyclization with N-O bond cleavage. Ready available nitrones were used as starting materials under simple metal-free reaction conditions, and various functional groups are compatible with this green protocol which can be carried out in one pot easily.