期刊
EXPERT REVIEW OF RESPIRATORY MEDICINE
卷 16, 期 5, 页码 529-540出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17476348.2022.2089117
关键词
Asthma; chronic obstructive pulmonary disease; fluticasone; formoterol; inhaled corticosteroid; long-acting beta 2-agonists; ICS-LABA
资金
- Cipla Ltd., India
This review summarizes the available literature on the efficacy and safety of FP/FORM in asthma and COPD patients, confirming that FP/FORM combination therapy is an effective and safe option for the treatment of persistent asthma and moderate-severe COPD.
Introduction: Fluticasone propionate/formoterol fumarate (FP/FORM) is one of the newer combinations among inhaled corticosteroid (ICS) and long-acting beta 2-agonist (LABA) combination formulations currently available. To evaluate the efficacy and safety of this FP/FORM combination, it is important to review all the available evidence and take a comprehensive look at the current and relevant data in the patient population suffering from asthma and chronic obstructive pulmonary disease (COPD). Areas covered: In this focused review, we summarize the available literature published until January 2021 using the PubMed/Medline and Cochrane Controlled Trials Register databases on the efficacy and safety of FP/FORM with its mono-components; concurrent administration of FP+FORM; and with other ICS/LABA combinations in asthma and COPD patients. Expert opinion: FP/FORM combination therapy is a strong alternative in the treatment of persistent asthma and moderate-severe COPD. Extensive study of several trials has established the superior efficacy of FP/FORM combination therapy over FP or FORM monotherapy, comparable efficacy with FP+FORM and non-inferiority to other ICS/LABA fixed-dose combinations. The safety profile of FP/FORM has also been found to be comparable with respect to its mono-components and their concurrent use, and also other ICS/LABA combinations such as formoterol/budesonide and fluticasone/salmeterol.
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