期刊
ACS APPLIED BIO MATERIALS
卷 5, 期 6, 页码 2935-2942出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.2c00268
关键词
second near-infrared; optical imaging; rare-earth nanoparticles; in vivo imaging; heavily doping
资金
- National Natural Science Foundation of China [21904023, 32171377, 22161160320]
- Science and Technology Commission of Shanghai Municipality [19490713100, 21QA1406700]
This article reports the synthesis of bright rare-earth based NIR-II downshifting nanoparticles and demonstrates their potential in monitoring cerebral vessels and tumor imaging in vivo.
The last decade has witnessed the booming development of optical imaging in the second near-infrared (NIR-II, 1000-1700 nm) window for disease screening and image-guided surgical interventions, due to the merits of multi-color observations and high spatio-temporal resolution in deep tissue. Therefore, bright and multispectral NIR-II probes are required and play a key role. Here, we report the synthesis of a set of bright rare-earth based NIR-II downshifting nanoparticles (DSNPs) with hexagonal phase (beta phase). As compared with the widely reported DSNPs (beta-NaYF4@NaYF4:20Yb/(0.5-2)A@NaYF4; A = Ho, Pr, Tm or Er) previously, we reveal that the concentrations of both sensitizers and activators can be further highly doped, not limited by the concentration quenching effect. Our results demonstrate that the optimized formula in the heavily doped DSNPs (beta-NaYF4@NaYbF4:A@NaYF4, A = 20Ho, 3Pr, 4Tm or 10Er) leads to 1.2- to 4.2-folds NIR-II luminescence enhancement. Especially for the heavily Er-doped DSNPs with long-wavelength photons extending to the NIR-IIb window (1500-1700 nm), we can further boost their luminescence through introducing a beneficial cross-relaxation and host matrix with higher phonon energy (cubic phase NaYF4@NaYbF4:10Er/5Ce@NaYF4), leading to a total of similar to 11.4-fold enhancement. The resulting biocompatible, bright NIR-II emitting DSNPs enable us to in vivo monitor the cerebral vessels through the intact scalp and skull, as well as two-color dynamic tumor imaging with high spatial resolution. This work suggests the potential of the heavily doped DSNPs for multiplexed imaging in cerebrovascular abnormalities toward the diagnosis and therapy of the cerebral diseases.
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