In Situ Synthesis of Gold Nanoclusters in Covalent Organic Frameworks with Enhanced Photodynamic Properties and Antibacterial Performance

In this work, ultrasmall gold nanoclusters (AuNCs) have been in situ synthesized in nanopores of covalent organic framework (COF) nanoparticles, which exhibited enhanced fluorescence, improved photosensitizing capabilities, and promising antibacterial performance. A small organic molecule, 1-vinylimidazole (Vim), was diffused into the nanopores of imine-based COFs and served as a reducing agent and capping ligand for the in situ synthesis of ultrasmall AuNCs. The as-obtained AuNCs were homogeneously distributed throughout the COF nanoparticles whose fluorescence intensity was enhanced remarkably. Due to the efficient electron transfer between AuNCs and COFs and increased separation of photogenerated electron-hole pairs, the light-triggered reactive oxygen species (ROS) production of COFs was prominently enhanced by AuNCs. Moreover, the obtained nanocomposites exhibited an efficient photodynamic killing behavior on Escherichia coli under visible light exposure. Thus, we provide a facile strategy to prepare COF/AuNC nanocomposites for ROS-related applications.

Automated summary

In this work, ultrasmall gold nanoclusters (AuNCs) were synthesized in situ in the nanopores of covalent organic framework (COF) nanoparticles, resulting in enhanced fluorescence, improved photosensitizing capabilities, and promising antibacterial performance. The incorporation of AuNCs into COFs led to efficient electron transfer and increased separation of photogenerated electron-hole pairs, significantly enhancing the light-triggered reactive oxygen species (ROS) production of COFs. The resulting nanocomposites exhibited efficient photodynamic killing on Escherichia coli under visible light exposure. This study provides a facile strategy for the preparation of COF/AuNC nanocomposites for ROS-related applications.