4.5 Review

The role of immune cells in the liver tumor microenvironment: an involvement of gut microbiota-derived factors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hiroki Murai et al.

Summary: Through the analysis of molecular abnormalities and tumor immune microenvironment in nonviral hepatocellular carcinoma, we identified the link between intratumoral steatosis and immune-exhausted immunotherapy-susceptible microenvironment.

HEPATOLOGY (2023)

Review Gastroenterology & Hepatology

The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases

Lingxuan An et al.

Summary: Hepatosteatosis is the earliest stage in the pathogenesis of nonalcoholic fatty liver disease and alcoholic liver disease, strongly linked with obesity. Gut dysbiosis and gut barrier dysfunction crucially contribute to the development of chronic liver disease. Treatments targeting the gut microbiome and gut barrier have shown potential benefits in attenuating liver inflammation.

JOURNAL OF GASTROINTESTINAL SURGERY (2022)

Review Oncology

Immunotherapies for hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, specifically hepatocellular carcinoma (HCC), is the second leading cause of cancer-related death globally. Traditional treatments involve specific drugs, but the emergence of immune checkpoint inhibitors has revolutionized the management of HCC.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

Article Multidisciplinary Sciences

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Erez N. Baruch et al.

Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.

SCIENCE (2021)

Article Oncology

Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma

Qianfei Zhang et al.

Summary: The study demonstrates that gut dysbiosis can lead to the accumulation of PMN-MDSCs, promoting liver cancer development. However, treatment with neomycin can block this process and inhibit tumor growth, even in the absence of liver disease or colitis.

CANCER DISCOVERY (2021)

Article Endocrinology & Metabolism

Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression

Nisreen Nimer et al.

Summary: Metabolomic studies have shown that plasma levels of bile acids are elevated in subjects with NAFLD compared to healthy controls. Specific bile acids are associated with the transition from simple hepatic steatosis to NASH, as well as genetic determinants. This suggests a potential role for bile acid metabolism in the development and progression of NASH.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

Article Multidisciplinary Sciences

Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients

Diwakar Davar et al.

Summary: The study demonstrated that fecal microbiota transplantation combined with anti-PD-1 therapy can overcome resistance to anti-PD-1 in a subset of PD-1 refractory melanoma patients, leading to clinical benefits. This approach induced changes in the gut microbiome and reprogrammed the tumor microenvironment, ultimately enhancing the efficacy of anti-PD-1 treatment.

SCIENCE (2021)

Review Gastroenterology & Hepatology

Overview of the microbiota in the gut-liver axis in viral B and C hepatitis

Maria Adriana Neag et al.

Summary: Hepatitis B and C are major health issues that can lead to chronic liver disease, cirrhosis, and hepatocellular carcinoma. Recent studies have shown the important interplay between the gut microbiome and the liver, with infections altering the gut microbiota and hindering the immune response. Restoring gut microbiota balance may help limit chronic changes in infected livers.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Article Multidisciplinary Sciences

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

Yuko Sato et al.

Summary: Centenarians have a unique gut microbiome enriched in microorganisms capable of producing specific bile acids, including a previously undescribed isoform. The specific bile acid isoalloLCA exhibits potent antimicrobial effects against Gram-positive multidrug-resistant pathogens, suggesting a potential role in reducing infection risk.

NATURE (2021)

Article Multidisciplinary Sciences

Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy

Matthew E. Griffin et al.

Summary: This study found that members of the Enterococcus bacterial genus can improve checkpoint inhibitor immunotherapy in mouse tumor models through the expression and secretion of immune-active murpeptides. Additionally, expression of this enzyme in nonprotective bacteria can also enhance immunotherapy response, requiring another bacterial sensor for its activity.

SCIENCE (2021)

Article Oncology

Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis

Noriho Iida et al.

Summary: The study revealed that Enterococcus faecalis is abundant in the microbiota of patients with hepatitis C virus-related chronic liver disease, promoting liver carcinogenesis via the TLR4-Myd88 signaling pathway.

NATURE CANCER (2021)

Article Gastroenterology & Hepatology

NASH-related increases in plasma bile acid levels depend on insulin resistance

Guillaume Grzych et al.

Summary: The study found that plasma bile acid concentrations are elevated only in NASH patients with significant insulin resistance, showing that they are not influenced by beta-cell function or BMI.

JHEP REPORTS (2021)

Review Nutrition & Dietetics

Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review

Michael W. Rohr et al.

ADVANCES IN NUTRITION (2020)

Article Gastroenterology & Hepatology

Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD

Guido Carpino et al.

HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

The characteristics and risk factors of hepatocellular carcinoma in nonalcoholic fatty liver disease without cirrhosis

Maki Tobari et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020)

Review Gastroenterology & Hepatology

Gut microbiome in HCC - Mechanisms, diagnosis and therapy

Robert F. Schwabe et al.

JOURNAL OF HEPATOLOGY (2020)

Article Biochemistry & Molecular Biology

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Mohsen Malehmir et al.

NATURE MEDICINE (2019)

Review Endocrinology & Metabolism

Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets

Jessica M. Ferrell et al.

DIABETES & METABOLISM JOURNAL (2019)

Review Gastroenterology & Hepatology

Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Wei Jia et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Article Multidisciplinary Sciences

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

V. Gopalakrishnan et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Bertrand Routy et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Localization of lipopolysaccharide from Escherichia Coli into human atherosclerotic plaque

Roberto Carnevale et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Vishal Singh et al.

Article Gastroenterology & Hepatology

Loss of lipopolysaccharide-binding protein attenuates the development of diet-induced non-alcoholic fatty liver disease in mice

Cheng Jun Jin et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2017)

Review Biochemistry & Molecular Biology

Mechanisms of bile acid mediated inflammation in the liver

Man Li et al.

MOLECULAR ASPECTS OF MEDICINE (2017)

Article Multidisciplinary Sciences

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Shabnam Shalapour et al.

NATURE (2017)

Article Gastroenterology & Hepatology

Small intestinal bacterial overgrowth and toll-like receptor signaling in patients with non-alcoholic fatty liver disease

Shweta Kapil et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2016)

Article Multidisciplinary Sciences

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Marie Vetizou et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang et al.

NATURE COMMUNICATIONS (2015)

Review Microbiology

Lipoteichoic Acid Synthesis and Function in Gram-Positive Bacteria

Matthew G. Percy et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 68 (2014)

Article Medicine, Research & Experimental

Bile acid dysregulation, gut dysbiosis, and gastrointestinal cancer

Jessica Tsuei et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2014)

Review Microbiology

Lipoteichoic Acids, Phosphate-Containing Polymers in the Envelope of Gram-Positive Bacteria

Olaf Schneewind et al.

JOURNAL OF BACTERIOLOGY (2014)

Article Multidisciplinary Sciences

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

Ikuo Kimura et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Gastroenterology & Hepatology

Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis

Natsuko Kawada et al.

JOURNAL OF GASTROENTEROLOGY (2009)

Article Multidisciplinary Sciences

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

Keigo Machida et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Gastroenterology & Hepatology

Bile acid levels are increased in the liver of patients with steatohepatitis

Marcia M. Aranha et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2008)

Article Gastroenterology & Hepatology

Small intestinal bacteria overgrowth decreases small intestinal motility in the NASH rats

Wan-Chun Wu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)

Article Biochemistry & Molecular Biology

TLR4 enhances TGF-β signaling and hepatic fibrosis

Ekihiro Seki et al.

NATURE MEDICINE (2007)

Review Multidisciplinary Sciences

Toll-like receptors in the induction of the innate immune response

A Aderem et al.

NATURE (2000)