The role of immune cells in the liver tumor microenvironment: an involvement of gut microbiota-derived factors

More than 500 species of microbiota reside in the human intestine and coexist with humans, their host. Gut microbial metabolites and components are absorbed from the intestine and influence cells in the liver, including hepatocytes and stromal cells, such as liver sinusoidal endothelial cells, hepatic stellate cells, Kupffer cells, natural killer (NK) cells, NK T cells and other immune cells. This gut-originated axis to the liver is called the gut-liver axis, which underscores the importance of the link between the gut and the liver. In this review, we discuss the gut microbial components and metabolites that affect cells in the liver, particularly in association with immune cells, and the related responses. We also highlight the mechanisms underlying gut microbiota-mediated liver carcinogenesis and discuss cancer prevention, including the recently clarified modulation of immune checkpoint inhibitor efficacy by the gut microbiota.

Automated summary

More than 500 species of microbiota in the human intestine coexist with host cells in the liver, including immune cells. This review discusses the impact of gut microbial components and metabolites on liver cells, especially immune cells, and the mechanisms underlying gut microbiota-mediated liver carcinogenesis, as well as cancer prevention.