期刊
BIOMATERIALS ADVANCES
卷 135, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bioadv.2022.212728
关键词
Zinc oxide; Photosensitizer; Antimicrobial effect; Reactive oxygen species; Wound healing
资金
- National Key Research and Development Program of China [2017YFE0103200]
- Natural Science Foundation of China [31670739, 22077016, 82070142]
- Natural Science Foundation of Fujian Province [2018J01897, 2018J01729]
In this study, ZnO microparticles loaded with phthalocyanine-type photosensitizers were developed to exhibit long-term while moderate antimicrobial effects by continuously releasing Zn2+ ions, and the antimicrobial efficacies were remarkably enhanced by triggering the photodynamic effects. In a dorsal wound infection mouse model, treatment with these ZnO microparticles significantly accelerated wound recovery rates by promoting tissue remodeling and efficiently eliminating pathogens, without causing noticeable toxicity.
ZnO is an important component in skin-protection products and wound-care medicines. However, ZnO's antibacterial activity is moderate. We developed two types of ZnO microparticles loading with phthalocyanine-type photosensitizers (ZnO/PSs) introducing the photodynamic effects. These photosensitive ZnO microparticles exhibited long-term while moderate antimicrobial effects by continuously releasing Zn2+ ions. The antimicrobial efficacies were remarkably enhanced by triggering the photodynamic antimicrobial effects. Compared to the sole ZnO which showed non-measurable antimicrobial activity at a concentration of 10 mg/L, both ZnO/PSs demonstrated antimicrobial rates ranged 99%???99.99% against Escherichia coli, normal and drug-resistant Staphylococcus aureus. In a dorsal wound infection mouse model, treatment with ZnO/PSs significantly accelerated the wound recovery rates. ZnO/PSs promoted wound healing by a dual effect: 1) the release of Zn2+ ions from ZnO facilitating tissue remodeling; 2) the photodynamic effect efficiently eliminates pathogens avoiding infection. Notably, ZnO/PSs inherited the high biosafety of ZnO without causing noticeable toxicity against erythrocyte and endothelial cells. This study not only provides a highly safe and efficient antimicrobial ZnO material for skin cares and wound modulations, but also proposes a strategy to functionalize ZnO materials.
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