期刊
ORGANIC CHEMISTRY FRONTIERS
卷 9, 期 15, 页码 4070-4077出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo00706a
关键词
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资金
- National Natural Science Foundation of China [21901100, 22161030, 51878326]
- Jiangxi Province Science and Technology Project [20204BCJ23010, 20202ACBL216017, 20212ACB203007, 20212AEI91002, 20202ACB203002]
- Jiangxi Educational Committee Foundation of China [GJJ210906, GJJ210909]
- Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University [2021ZD01]
This article describes a copper-promoted reductive cross-coupling of nitroarenes with 4-alkyl-1,4-dihydropyridines to produce N-alkylbenzenamines. The reaction enables the construction of C(sp(3))-N bonds under oxidative conditions, providing an elegant platform for assembling N-alkylbenzenamines with good tolerance for sensitive functional groups.
A copper-promoted reductive cross-coupling of nitroarenes with 4-alkyl-1,4-dihydropyridines for producing N-alkylbenzenamines is described. Using 4-alkyl-1,4-dihydropyridines as alkyl radical sources and internal reducing agents enables the construction of C(sp(3))-N bonds under oxidative conditions, which provide an elegant complementary platform to assemble N-alkylbenzenamines with good tolerance for sensitive functional groups.
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