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Hydrogels for Exosome Delivery in Biomedical Applications

GELS (2022)

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Osteoblast/Osteoclast and Immune Cocktail Therapy of an Exosome/Drug Delivery Multifunctional Hydrogel Accelerates Fracture Repair

Bobin Mi et al.

Summary: The ratios of osteoblast/osteoclast and M1/M2 macrophages are crucial for fracture healing. This study developed a cocktail therapy to simultaneously regulate the balance of these cells, leading to enhanced fracture repair. Each component of the cocktail therapy was found to be indispensable, providing insight into synergistic strategies for fracture repair.

ACS NANO (2022)

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Article Engineering, Biomedical

Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration

Qiaomei Tang et al.

Summary: In this study, a novel approach based on exosomes and a thermosensitive hydrogel was developed for the treatment of corneal diseases. This method effectively reduces scar formation and accelerates the healing process by promoting the repair of damaged corneal epithelium and stromal layer.

BIOMATERIALS (2022)

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Article Materials Science, Biomaterials

Higher yield and enhanced therapeutic effects of exosomes derived from MSCs in hydrogel-assisted 3D culture system for bone regeneration

Wenting Yu et al.

Summary: In this study, a 3D culture model was engineered to enhance the osteoinductivity of MSC-derived exosomes. Exosomes derived from 3D culture showed higher yield and improved efficiency of collection compared to conventional monolayer culture. Moreover, these exosomes significantly promoted osteogenic gene and protein expression, proliferation, and migration of bone marrow mesenchymal stem cells. Mechanistic studies revealed that the upregulation of the YAP signaling pathway is the underlying mechanism. The 3D-Exos also resulted in enhanced new bone formation in rats with alveolar bone defects.

BIOMATERIALS ADVANCES (2022)

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Article Biotechnology & Applied Microbiology

Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis

Yu Zhang et al.

Summary: This study aims to investigate the application of PRP-Exo in the treatment of subtalar osteoarthritis (STOA) caused by chronic ankle sprains. By incorporating PRP-Exo in a thermosensitive hydrogel (Gel), it was confirmed that Exo-Gel increased the retention of Exo in the joint and had a therapeutic effect. In vitro experiments showed that Exo-Gel promoted the proliferation and migration of bone mesenchymal stem cells and chondrocytes, as well as enhanced chondrogenic differentiation. In vivo experiments demonstrated that Exo-Gel inhibited apoptosis and hypertrophy of chondrocytes, enhanced proliferation, and potentially delayed the development of STOA.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Bone Mesenchymal Stem Cell-Derived sEV-Encapsulated Thermosensitive Hydrogels Accelerate Osteogenesis and Angiogenesis by Release of Exosomal miR-21

Di Wu et al.

Summary: This study developed injectable thermosensitive hydrogel-encapsulated small extracellular vesicles (sEVs) that displayed excellent biocompatibility and enhanced bone regeneration. Mechanistic studies revealed that exosomal miR-21 targeted SPRY2, thereby promoting angiogenesis. This research provides new insights and potential for tissue repair in the future.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Engineering, Biomedical

Extracellular Vesicles from 3D Engineered Microtissues Harbor Disease-Related Cargo Absent in EVs from 2D Cultures

Christopher Millan et al.

Summary: Engineered microtissues have a significant impact on extracellular vesicles (EVs) secreted by benign and malignant prostate cells, with a higher yield of EVs per cell in 3D cultures compared to 2D. Whole transcriptome sequencing and proteomics analysis reveal stark contrasts in molecular cargo between 2D-EVs and 3D-EVs, with exclusive enrichment of known drivers of prostate cancer progression in 3D-EVs. Functional assays demonstrate that only 3D-EVs confer increased invasiveness and chemoresistance to cells in 2D, highlighting the potential of engineered 3D microtissue cultures for identifying biomarkers not detectable in standard 2D conditions.

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Article Engineering, Biomedical

Design and characterization of an in vivo injectable hydrogel with effervescently generated porosity for regenerative medicine

Louise Griveau et al.

Summary: This study introduces an injectable hydrogel that forms porosity in vivo through a controlled effervescent reaction. The hydrogel, crosslinked by the reaction of polyethylene glycol with lysine dendrimers, forms highly interconnected porous networks by entrapping CO2 bubbles. The resulting hydrogels have cytocompatibility, modular mechanical properties, and support tissue remodeling and neovascularization, making them promising for clinical tissue repair.

ACTA BIOMATERIALIA (2022)

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Therapeutically harnessing extracellular vesicles

Lesley Cheng et al.

Summary: The field of extracellular vesicle (EV) research has rapidly developed and is now recognized for its potential in the treatment and diagnosis of diseases. This article provides an overview of the characteristics and physiological functions of EVs, their association with diseases, and the strategies for their therapeutic exploitation.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Engineering, Biomedical

Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair

Pengfei Guan et al.

Summary: Growth plate cartilage has limited self-repair ability, leading to poor bone bridge formation and limb growth defects in children. The researchers developed an exosome-derived hydrogel that directly supplements extracellular matrix and inhibits inflammation to promote cartilage repair. The hydrogel significantly enhanced extracellular matrix synthesis and facilitated growth plate injury repair through ECM remodeling.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

Photoacoustic image-guided corpus cavernosum intratunical injection of adipose stem cell-derived exosomes loaded polydopamine thermosensitive hydrogel for erectile dysfunction treatment

Li Liang et al.

Summary: In this study, PDNPs-incorporated hydrogels were developed for sustained release of adipose stem cell-derived exosomes (EXO) and restoration of erectile function. The PDNPs in the hydrogels exhibited excellent photoacoustic performance, enabling accurate delivery into the tunica albuginea.

BIOACTIVE MATERIALS (2022)

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Article Cardiac & Cardiovascular Systems

Human Umbilical Cord Mesenchymal Stem Cell Derived Exosomes Delivered Using Silk Fibroin and Sericin Composite Hydrogel Promote Wound Healing

Chaoshan Han et al.

Summary: Recent research has demonstrated that hydrogels formed by composite biomaterials, particularly those consisting of silk fibroin and silk sericin, exhibit superior performance in tissue repair by promoting wound healing, angiogenesis, and reducing inflammation. These composite hydrogels can serve as an excellent delivery system for exosomes in tissue repair.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Nanoscience & Nanotechnology

Restoring Cardiac Functions after Myocardial Infarction-Ischemia/Reperfusion via an Exosome Anchoring Conductive Hydrogel

Yang Zou et al.

Summary: A novel injectable conductive hydrogel was designed for treating myocardial injuries after myocardial infarction. The hydrogel, containing exosomes derived from stem cells cross-linked via an epoxy/thiol click reaction, effectively improved cardiac functions, promoted cell-to-cell interactions, and angiogenesis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

ECM stiffness-tuned exosomes drive breast cancer motility through thrombospondin-1

Sejal Patwardhan et al.

Summary: Exosomes play a significant role in breast cancer invasiveness triggered by ECM stiffness. High ECM stiffness promotes exosome secretion in a YAP/TAZ pathway-dependent manner, leading to changes in cell morphology, adhesion, and protrusion dynamics that enhance cell motility and invasion. Exosomes from stiff ECM cultures exhibit enrichment of cell adhesion and migration proteins, with thrombospondin-1 identified as a prospective regulator of stiffness-dependent cancer invasion mediated by exosomal communication.

BIOMATERIALS (2021)

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Article Polymer Science

Biodegradable polymers in drug delivery and oral vaccination

Pradip Jana et al.

Summary: Biodegradable polymers have emerged as promising materials in drug delivery and vaccination due to their biocompatibility, biodegradability, and minimal toxicity. Targeting mucosal immune system in particulate carriers for oral vaccine delivery can provide desired immunological response for longer period without the need for repetitive injections or skilled personnel.

EUROPEAN POLYMER JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Hydrogel Encapsulation of Mesenchymal Stem Cells and Their Derived Exosomes for Tissue Engineering

Parisa Khayambashi et al.

Summary: Tissue engineering has a long history in regenerative medicine, and methods such as cell-encapsulated hydrogels and exosomes can enhance the regenerative potential of various tissues, with hydrogels being the most user-friendly, economical, and accessible material for encapsulation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

Maurice N. Collins et al.

Summary: Bone tissue engineering aims to create biofunctional tissue for treating diseases, with scaffold fabrication techniques and biomaterial selection being crucial. Vascularization and immunomodulation are major challenges in this field.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Plant Exosomes As Novel Nanoplatforms for MicroRNA Transfer Stimulate Neural Differentiation of Stem Cells In Vitro and In Vivo

Xue-Han Xu et al.

Summary: Exosomes derived from ginseng were shown to efficiently promote neural differentiation of BMSCs by transferring miRNAs, demonstrating potential for neural regenerative medicine both in vitro and in vivo.

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Article Chemistry, Multidisciplinary

Microenvironment-Protected Exosome-Hydrogel for Facilitating Endometrial Regeneration, Fertility Restoration, and Live Birth of Offspring

Jiaying Lin et al.

Summary: Thin endometrium can lead to failed embryo transfer and long-term infertility, but a multifunctional microenvironment-protected exosome-hydrogel has been designed to promote endometrial regeneration and fertility restoration while reducing infection risk. This system shows promising results in promoting neovascularization and tissue regeneration, making the regenerated endometrial tissue more receptive to embryos and leading to the birth of healthy newborns.

SMALL (2021)

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Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

Dashuai Zhu et al.

Summary: Intrapericardial injection is established as a safe and effective method for delivering therapeutic-bearing hydrogels to the heart, promoting cardiac repair.

NATURE COMMUNICATIONS (2021)

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Article Nanoscience & Nanotechnology

Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels Accelerate Bone Repair by Enhancing Angiogenesis

Yuntong Zhang et al.

Summary: Repairing large bone defects remains a major challenge for orthopedic surgeons, but this study demonstrates a promising strategy using umbilical MSC-derived exosomes in combination with hyaluronic acid hydrogel and nanohydroxyapatite/poly-epsilon-caprolactone scaffolds to enhance bone regeneration in rats. The exosomes were found to promote angiogenesis and potentially regulate it through the miR-21/NOTCH1/DLL4 signaling axis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

3D Encapsulation and tethering of functionally engineered extracellular vesicles to hydrogels

Chun-Chieh Huang et al.

Summary: This study developed a method to encapsulate MSC-derived EVs in 3D hydrogels for prolonged delivery by leveraging interactions with ECM proteins, showing enhanced bone regeneration in in vivo models. The technology has the potential for controlled delivery of EVs in various regenerative medicine applications.

ACTA BIOMATERIALIA (2021)

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Review Chemistry, Multidisciplinary

Soft Materials by Design: Unconventional Polymer Networks Give Extreme Properties

Xuanhe Zhao et al.

Summary: Hydrogels possess extreme mechanical properties and have diverse applications. While many hydrogels have been developed, a set of general principles for designing them for various applications remains a central need.

CHEMICAL REVIEWS (2021)

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Article Engineering, Biomedical

Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis

Shi-Cong Tao et al.

Summary: OA is a common age-related degenerative joint disease with disturbance of ECM balance. CircRNA3503, increased after MT-induced cell sleep, acts as a sponge of hsa-miR-181c-3p and hsa-let-7b-3p to rescue IL-1 beta effects on OA. PLEL@circRNA3503-OE-sEVs show potential as an effective therapeutic strategy to prevent OA progression.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction

Marta Monguio-Tortajada et al.

Summary: The study presents a novel MSC-EV delivery approach for cardiac repair, showing significant effects in reducing immune response, promoting angiogenesis, and reducing inflammation. The research demonstrates the potential therapeutic efficacy of loading EV in engineered pericardial scaffolds for treating myocardial infarction.

BIOACTIVE MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone Regeneration

Elham Pishavar et al.

Summary: Hydrogels, when combined with exosomes, contribute to improving methodologies in bone tissue engineering and play a crucial role in tissue repair and remodeling.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Nanoscience & Nanotechnology

Extracellular vesicles as a next-generation drug delivery platform

Inge Katrin Herrmann et al.

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NATURE NANOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

A novel delivery nanobiotechnology: engineered miR-181b exosomes improved osteointegration by regulating macrophage polarization

Wei Liu et al.

Summary: Exosomes overexpressing miR-181b (Exo-181b) can enhance M2 macrophage polarization, inhibit inflammation, promote osteogenesis, and enhance osteointegration in both in vitro and in vivo studies.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Hydrogel-load exosomes derived from dendritic cells improve cardiac function via Treg cells and the polarization of macrophages following myocardial infarction

Youming Zhang et al.

Summary: A novel drug delivery system incorporating alginate hydrogel was developed to continuously release DEXs, enhancing the therapeutic effects of DEXs in improving cardiac function after MI.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration

Hongyuan Xing et al.

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HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction

Qingjie Wang et al.

Summary: EVs derived from HIF-1α-engineered MSCs can promote angiogenesis of endothelial cells and apoptosis of cardiomyocytes through upregulating the expression of miR-221-3p. Additionally, RGD hydrogels can enhance the therapeutic efficacy of these EVs.

MATERIALS TODAY BIO (2021)

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Exosome loaded genipin crosslinked hydrogel facilitates full thickness cutaneous wound healing in rat animal model

Qijun Li et al.

Summary: This study utilized a dual-sensitive hydrogel loaded with exosomes derived from hUCMSCs to promote wound healing and skin regeneration, showing significant improvements in wound closure, re-epithelialization rates, and collagen deposition in the wound sites. The results suggest the potential for achieving complete skin regeneration through the use of this novel approach.

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Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-beta-induced neurotoxicity

Zhiting Deng et al.

Summary: The study showed that ultrasound stimulation can enhance the release of exosomes from astrocytes, which have neuroprotective effects against Aβ toxicity. When combined with ultrasound-induced blood-brain-barrier opening, it enables the clearance of Aβ plaques in the brain.

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ACTA BIOMATERIALIA (2020)

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Dandan Su et al.

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Review Nanoscience & Nanotechnology

The design of reversible hydrogels to capture extracellular matrix dynamics

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NATURE REVIEWS MATERIALS (2016)

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Designing hydrogels for controlled drug delivery

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NATURE REVIEWS MATERIALS (2016)

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Article Multidisciplinary Sciences

Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo

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SCIENTIFIC REPORTS (2016)

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Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey

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JOURNAL OF EXTRACELLULAR VESICLES (2016)

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Acoustic Purification of Extracellular Microvesicles

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ACS NANO (2015)

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Review Engineering, Biomedical

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

Kan Yue et al.

BIOMATERIALS (2015)

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Review Biochemical Research Methods

Mass-Spectrometry-Based Molecular Characterization of Extracellular Vesicles: Lipidomics and Proteomics

Simion Kreimer et al.

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Exosomal RNA from Mycobacterium tuberculosis-Infected Cells Is Functional in Recipient Macrophages

Prachi Pratap Singh et al.

TRAFFIC (2015)

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Supramolecular hydrogels: synthesis, properties and their biomedical applications

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BIOMATERIALS SCIENCE (2015)

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Physically crosslinked polyvinyl alcohol and gelatin interpenetrating polymer network theta-gels for cartilage regeneration

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Challenges in the Treatment of Chronic Wounds

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ADVANCES IN WOUND CARE (2015)

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Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer

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Optimized exosome isolation protocol for cell culture supernatant and human plasma

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JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice

Takafumi Imai et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Letter Cell Biology

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

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CELL RESEARCH (2014)

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Crosslinking of collagen scaffolds promotes blood and lymphatic vascular stability

Kelvin L. S. Chan et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)

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Collagen hydrogel as an immunomodulatory scaffold in cartilage tissue engineering

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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2014)

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Hydrogels in a historical perspective: From simple networks to smart materials

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JOURNAL OF CONTROLLED RELEASE (2014)

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Regulation of immune responses by extracellular vesicles

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Single-step isolation of extracellular vesicles by size-exclusion chromatography

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JOURNAL OF EXTRACELLULAR VESICLES (2014)

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Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles

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Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

Bas W. M. van Balkom et al.

BLOOD (2013)

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Extracellular vesicles: biology and emerging therapeutic opportunities

Samir EL Andaloussi et al.

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Increased Shedding of Microvesicles from Intimal Smooth Muscle Cells in Athero-Prone Areas of the Human Aorta: Implications for Understanding of the Predisease Stage

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Extracellular vesicle sizing and enumeration by nanoparticle tracking analysis

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Novel crosslinking methods to design hydrogels

W. E. Hennink et al.

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Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells

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KIDNEY INTERNATIONAL (2012)

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Article Biochemistry & Molecular Biology

Collagen-Reinforced Electrospun Silk Fibroin Tubular Construct as Small Calibre Vascular Graft

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Human Embryonic Mesenchymal Stem Cell-Derived Conditioned Medium Rescues Kidney Function in Rats with Established Chronic Kidney Disease

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PLOS ONE (2012)

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Review Chemistry, Physical

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SOFT MATTER (2012)

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Article Chemistry, Multidisciplinary

Hyaluronic Acid Hydrogels for Biomedical Applications

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ADVANCED MATERIALS (2011)

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Hydrogel design for cartilage tissue engineering: A case study with hyaluronic acid

Iris L. Kim et al.

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Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

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COLLOIDS AND SURFACES B-BIOINTERFACES (2011)

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The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells

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Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

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Endosome-lysosome fusion

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BIOCHEMICAL SOCIETY TRANSACTIONS (2010)

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Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells

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BIOMATERIALS (2010)

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Stereocontrolled ring-opening polymerisation of lactide

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CHEMICAL SOCIETY REVIEWS (2010)

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Membrane budding and scission by the ESCRT machinery: it's all in the neck

James H. Hurley et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

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Cellular Internalization of Exosomes Occurs Through Phagocytosis

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TRAFFIC (2010)

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Magnetic nanoparticles for biomedical NMR-based diagnostics

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BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2010)

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Breathing-In/Breathing-Out Approach to Preparing Nanosilver-Loaded Hydrogels: Highly Efficient Antibacterial Nanocomposites

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JOURNAL OF APPLIED POLYMER SCIENCE (2009)

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Article Biochemical Research Methods

ExoCarta: A compendium of exosomal proteins and RNA

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PROTEOMICS (2009)

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The thrombogenicity of human umbilical vein endothelial cell seeded collagen modules

Alison P. McGuigan et al.

BIOMATERIALS (2008)

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Article Biochemical Research Methods

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

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JOURNAL OF PROTEOME RESEARCH (2008)

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Article Polymer Science

Design and fabrication of a high-strength hydrogel with ideally homogeneous network structure from tetrahedron-like macromonomers

Takamasa Sakai et al.

MACROMOLECULES (2008)

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Review Cell & Tissue Engineering

Cell encapsulation in biodegradable hydrogels for tissue engineering applications

Garret D. Nicodemus et al.

TISSUE ENGINEERING PART B-REVIEWS (2008)

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Review Cell & Tissue Engineering

Fibrin: A versatile scaffold for tissue engineering applications

Tamer A. E. Ahmed et al.

TISSUE ENGINEERING PART B-REVIEWS (2008)

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi et al.

NATURE CELL BIOLOGY (2007)

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Stimulation of neurite outgrowth by neurotrophins delivered from degradable hydrogels

JA Burdick et al.

BIOMATERIALS (2006)

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Review Pharmacology & Pharmacy

In situ-forming hydrogels -: review of temperature-sensitive systems

E Ruel-Gariépy et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2004)

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Integrative repair of cartilage with articular and nonarticular chondrocytes

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TISSUE ENGINEERING (2004)

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Review Engineering, Biomedical

Hydrogels for tissue engineering: scaffold design variables and applications

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BIOMATERIALS (2003)

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Review Immunology

Exosomes:: Composition, biogenesis and function

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NATURE REVIEWS IMMUNOLOGY (2002)

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Article Immunology

TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/ζ complex

N Blanchard et al.

JOURNAL OF IMMUNOLOGY (2002)

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Article Engineering, Biomedical

The effects of cross-linking of collagen-glycosaminoglycan scaffolds on compressive stiffness, chondrocyte-mediated contraction, proliferation and biosynthesis

CR Lee et al.

BIOMATERIALS (2001)

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Article Chemistry, Multidisciplinary

A survey of structure-property relationships of surfaces that resist the adsorption of protein

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LANGMUIR (2001)

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Article Engineering, Biomedical

Control of pore structure and size in freeze-dried collagen sponges

H Schoof et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH (2001)

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Review Biotechnology & Applied Microbiology

Bacterial alginate: physiology, product quality and process aspects

W Sabra et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2001)

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Review Pharmacology & Pharmacy

Biomedical applications of collagen

CH Lee et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2001)

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Influence of the degradation mechanism of hydrogels on their elastic and swelling properties during degradation

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MACROMOLECULES (2000)

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Making microencapsulation work: conformal coating, immobilization gels and in vivo performance

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JOURNAL OF CONTROLLED RELEASE (2000)

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