Functional assignment to hypothetical proteins in Orientia tsutsugamushi strain Ikeda

Orientia tsutsugamushi (O. tsutsugamushi) is an intracellular bacterial pathogen which causes zoonosis scrub typhus in humans. Genome of O. Tsutsugamushi strain Ikeda contains 214 hypothetical proteins (HPs) which is nearly 20% of the total proteins. Domain and family based functional analysis of HPs results in the annotation of 44 hypothetical proteins. The annotated HPs were classified in to five main classes namely, gene expression and regulation, transport, metabolism, cell signaling and proteolysis. Thus, computational analysis of HPs helps to understand their putative roles in various biological and cellular processes, including pathogenesis for further consideration as potential therapeutic targets.

Automated summary

Orientia tsutsugamushi is an intracellular bacterial pathogen that causes zoonotic scrub typhus in humans. The genome of O. Tsutsugamushi contains 214 hypothetical proteins, of which the functions of 44 have been annotated. These annotated proteins are classified into five main classes and their computational analysis provides insights into potential therapeutic targets for understanding their roles in various biological and cellular processes, including pathogenesis.