期刊
SOFT MATTER
卷 18, 期 26, 页码 4991-5000出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2sm00578f
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资金
- Key Research and Development Program of Shandong Province of China [2019JZZY010338]
- Scientific and Technological Innovation Major Project of Taian [2021ZDZX021]
- Scientific and Technological Innovation Major Project of Hubei Province of China [2021BEC014]
- Application Foundation Frontier Project of Wuhan Science and Technology Bureau [2020010601012194]
- National Natural Science Foundation of China [51873166, U20A20257]
In this study, a robust and antifouling polyvinyl alcohol nanofibrous sterile membrane was successfully fabricated, with high hydrophilicity and anti-pollution properties, making it suitable for sterile filtration of biological drug products.
Constructing a sterile membrane with a robust and antifouling surface is a powerful means to improve the sterile filtration efficiency of sterile membranes. In this work, a robust EVOH nanofibrous sterile membrane was facilely fabricated by the method of in situ crosslinking with glutaraldehyde and surface plasma treatment. The resultant EVOH nanofibrous sterile membrane possessed a carboxylated-crosslinked surface, with high hydrophilicity, which generated high chemical stability, high-temperature steam resistance, and an ultrahigh antifouling performance against bovine serum albumin, ribonucleic acid and nanoparticle pollutants. Moreover, the membrane also exhibited a reasonably high primary water permeance (4522.2 LMH bar(-1) at 0.2 MPa), as well as an absolute interception rate (100%) of Escherichia coli, Staphylococcus aureus cells and Brevundimonas diminuta superior to the state-of-the-art sterile membrane. Moreover, the modified membrane packed syringe-driven filter presented 100% interception (LRV >= 7) to Brevundimonas diminuta and high permeation flux (from 10.8 to 41.8 L center dot h(-1)) in a wide operating pressure range of 0.1 MPa to 0.6 MPa, indicating its potential in real bio-separation applications. This work provides a facile strategy for the preparation of a high-performance sterile membrane for biological drug product sterilization.
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