期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.918896
关键词
SARS-CoV-2; COVID-19; vaccine; immune response; coronavac; BNT162b2; heterologous booster
类别
资金
- Oswaldo Cruz Foundation (FIOCRUZ)
- Innovative Products to face COVID-19 pandemics initiative [VPPIS-005-FIO-20-2-45]
- Brazilian Ministry of Science, Technology and Innovation (MCTI) [FINEP 01.20.0005.00]
- Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES)
- FIOCRUZ
- Brazilian National Council for Scientific and Technological Development (CNPq)
- CNPq
- FAPEAM (PVN-II, PRO-ESTADO Program) [005/2019]
- FAPESP [2020/07419-0]
- Centers for Research in Emerging Infectious Diseases (CREID) by the National Institutes of Health (NIH/USA) [U01 AI151807]
- FAPESP COVID Grant [2020/048360]
This study focuses on the effectiveness of the combination of the CoronaVac vaccine and the BNT162b2 booster in immune response. The results show that the CoronaVac vaccine increases the antibody levels, which decline after 80 days but recover after the introduction of the booster. The neutralizing antibody titers against the Delta variant are higher than those against the Omicron variant. The cellular immune response after CoronaVac vaccination releases a significant amount of chemokines, cytokines, and growth factors in the first month, which gradually decreases over time and does not increase after the booster. Individuals with prior exposure to the virus show a more robust cellular immune response and an increase in antibody levels 60 days post CoronaVac vaccination.
BackgroundEffective and safe vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are critical to controlling the COVID-19 pandemic and will remain the most important tool in limiting the spread of the virus long after the pandemic is over. MethodsWe bring pioneering contributions on the maintenance of the immune response over a year on a real-life basis study in 1,587 individuals (18-90 yrs, median 39 yrs; 1,208 female/379 male) who underwent vaccination with two doses of CoronaVac and BNT162b2 booster after 6-months of primary protocol. FindingsElevated levels of anti-spike IgG antibodies were detected after CoronaVac vaccination, which significantly decreased after 80 days and remained stable until the introduction of the booster dose. Heterologous booster restored antibody titers up to-1 center dot 7-fold, changing overall seropositivity to 96%. Titers of neutralising antibodies to the Omicron variant were lower in all timepoints than those against Delta variant. Individuals presenting neutralising antibodies against Omicron also presented the highest titers against Delta and anti-Spike IgG. Cellular immune response measurement pointed out a mixed immune profile with a robust release of chemokines, cytokines, and growth factors on the first month after CoronaVac vaccination followed by a gradual reduction over time and no increase after the booster dose. A stronger interaction between those mediators was noted over time. Prior exposure to the virus leaded to a more robust cellular immune response and a rise in antibody levels 60 days post CoronaVac than in individuals with no previous COVID-19. Both vaccines were safe and well tolerated among individuals. InterpretationOur data approach the effectiveness of CoronaVac association with BNT162b2 from the clinical and biological perspectives, aspects that have important implications for informing decisions about vaccine boosters. FundingFiocruz, Brazil.
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