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Review
Allergy
Bryan Oronsky et al.
Summary: Persistent post-COVID syndrome, a pathologic entity, involves persistent physical, medical, and cognitive sequelae following COVID-19. The syndrome includes immunosuppression and organ fibrosis, and its potential long-term effects place a burden on healthcare systems, patients' families, and society.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Joachim P. Sturmberg et al.
Summary: COVID-19 has highlighted the vulnerable state of global health and social systems, calling for enhanced emergency health crisis preparedness, integrated policy frameworks, and clear communication. It is essential to establish a robust distributed health system and transparent communication to build trust in the system. Additionally, systems thinking and complexity sciences should inform the redesign of strong health systems to address the current health crisis and create healthy, resilient, and productive communities.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2022)
Review
Primary Health Care
P. Espinosa Rodriguez et al.
Summary: Clinical sequelae of widespread COVID-19 are important in primary care, with long COVID potentially being myalgic encephalomyelitis. Comparing diagnosis criteria and symptoms, similarities are observed. Various tests are recommended for patients with persistent symptoms after acute infection. Management involves treating the main symptoms, and long-term follow-up is essential due to the possibility of COVID-19 leading to a chronic condition like myalgic encephalomyelitis.
MEDICINA DE FAMILIA-SEMERGEN
(2022)
Article
Medicine, General & Internal
Matthew E. Oster et al.
Summary: Based on reports in the US, the risk of myocarditis after receiving mRNA-based COVID-19 vaccines was increased, especially among adolescent males and young men, particularly after the second dose. This risk should be considered in the context of the benefits of COVID-19 vaccination.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Martina Patone et al.
Summary: The study found that there is an increased risk of myocarditis associated with the first dose of ChAdOx1 and BNT162b2 vaccines, as well as the first and second doses of the mRNA-1273 vaccine in the 1-28 days post-vaccination period. Additionally, individuals with SARS-CoV-2 infection also face a greater risk of myocarditis, pericarditis, and cardiac arrhythmia.
Article
Chemistry, Medicinal
Rui Wang et al.
Summary: The surge of COVID-19 infections has been fueled by new SARS-CoV-2 variants. Understanding the molecular mechanism of SARS-CoV-2 transmission and evolution is crucial for predicting emerging vaccine-breakthrough variants and designing mutation-proof vaccines and monoclonal antibodies. This study integrates genotyping, antibody libraries, mutational data, topological data analysis, and deep learning to reveal the evolution mechanism of SARS-CoV-2 and forecast vaccine-breakthrough variants.
ACS INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Imad M. Tleyjeh et al.
Summary: A study was conducted to determine predictors of different functional outcomes after hospital discharge in COVID-19 patients, showing several risk factors associated with an increased risk of PACS. Factors such as female gender, older age, pre-existing lung disease, and emergency room visits may influence patients' recovery outcomes.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Hamza Mimouni et al.
Summary: This article discusses the phenomenon of myocarditis after COVID-19 vaccination through a case report. Although there have been reports of myocarditis cases after vaccination, there is still no definitive causal link. Further investigation is needed to obtain more relevant information.
ANNALS OF MEDICINE AND SURGERY
(2022)
Review
Immunology
Felicia Ceban et al.
Summary: Post-COVID-19 syndrome, characterized by persistent symptoms after resolution of acute infection, is associated with significant fatigue and cognitive impairment. This study aimed to quantify the proportion of individuals experiencing fatigue and cognitive impairment 12 or more weeks after COVID-19 diagnosis, and to explore the inflammatory and functional consequences of post-COVID-19 syndrome. The results showed that a significant proportion of individuals continue to experience fatigue and cognitive impairment even after 12 or more weeks of COVID-19 diagnosis. Additionally, some individuals showed elevated levels of inflammatory markers and significant functional impairment.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Medicine, General & Internal
Maurish Fatima et al.
Summary: Myocarditis and pericarditis have been reported after COVID-19 vaccination, particularly in young adult males and most commonly after the second dose. The presentation is generally mild, and the majority of patients recover either completely or partially.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Medicine, General & Internal
Abdulbaril Olagunju et al.
Summary: Viral infections and vaccines, including the COVID-19 vaccine, have been associated with acute myocarditis. We describe a case of a 19-year-old male who developed acute myocarditis two days after receiving the COVID-19 mRNA-1273 vaccine. The patient's symptoms resolved after treatment.
JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS
(2022)
Review
Public, Environmental & Occupational Health
Florence Moncorps et al.
Summary: The study compared coping strategies of patients with ME/CFS to those with other chronic conditions and found that ME/CFS patients have significantly different coping strategies, particularly in seeking social support and problem-solving.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Article
Health Policy & Services
Jorge Simoes et al.
Summary: The time and type of responses to the COVID-19 pandemic varied among different countries depending on the severity of the epidemiological situation, perceived risk, political organisation, and health system model. Success in tackling the epidemic seemed to be more influenced by other social determinants of health rather than the differences in political models and health systems.
INTERNATIONAL JOURNAL OF HEALTH PLANNING AND MANAGEMENT
(2021)
Article
Cardiac & Cardiovascular Systems
Holger M. Nef et al.
Summary: During the COVID-19 lockdown period in central Germany, cardiovascular mortality significantly increased while catheterization activities decreased. Further investigations are needed to understand the mechanisms behind these observations.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
L. V. Shogenova et al.
CARDIOVASCULAR THERAPY AND PREVENTION
(2021)
Article
Medicine, General & Internal
Arush Lal et al.
Summary: The COVID-19 pandemic has highlighted the importance of strengthening global health security and universal health coverage, as well as the need for integration, financing, resilience, and equity in governance, policies, and investments for better health outcomes. By comparing different health systems' responses to the pandemic, essential lessons can be drawn for creating a more sustainable future.
Article
Immunology
Karen B. Jacobson et al.
Summary: The study assessed 118 individuals 3-4 months after their initial COVID-19 diagnosis and found significant persistent symptoms and functional impairment, even in non-hospitalized patients with COVID-19.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Environmental Sciences
Kazimieras Melaika et al.
Summary: The study compared prehospital stroke care before and during COVID-19 lockdown, showing a decrease in stroke alerts and admissions, as well as a decline in prehospital stroke triage quality during the lockdown. Longer onset-to-door time was observed during the lockdown, along with increased prevalence of seizures and intracranial tumors among stroke mimics.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Cesar Fernandez-de-las-Penas et al.
Summary: The symptoms of long-haulers of COVID-19 can be classified into potentially infection-related, acute post-COVID, long post-COVID, and persistent post-COVID stages. Establishing time reference points is crucial, while the plethora of symptoms affecting multiple systems suggests the presence of different underlying mechanisms.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medical Informatics
Nicholas R. J. Frick et al.
Summary: The COVID-19 pandemic has greatly impacted collaboration among medical specialists in health care systems worldwide. Digital transformation plays a crucial role in driving virtual collaboration among clinicians in hospitals during crisis. It is essential to align stakeholders' mindsets, establish behavioral rules, and implement a suitable technological infrastructure to ensure goal-driven collaboration.
JMIR MEDICAL INFORMATICS
(2021)
Article
Medicine, General & Internal
Anders Husby et al.
Summary: This study investigated the association between SARS-CoV-2 vaccination and myocarditis or myopericarditis, finding an increased risk of developing these conditions within 0-28 days post-vaccination, especially among individuals aged 12-39 and males.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Review
Medicine, Research & Experimental
Androula Pavli et al.
Summary: Post-COVID syndrome, also known as long COVID, refers to symptoms persisting for more than three weeks after the diagnosis of COVID-19, with an estimated incidence of 10-35%. Common symptoms include fatigue, residual dyspnea, mental problems, chest pain, as well as olfactory and gustatory dysfunction. Most patients have a good prognosis with no further complications or fatal outcomes reported.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Review
Public, Environmental & Occupational Health
Aliza Petiwala et al.
Summary: This study focuses on health-oriented collaboration and community voice, revealing various community voice concepts and strategies that fall on a spectrum between active and passive approaches. Understanding these strategies can lead to improved health outcomes and increased cross-sector alignment.
Article
Cardiac & Cardiovascular Systems
Donna M. Mancini et al.
Summary: The study showed that circulatory impairment, abnormal ventilatory pattern, and ME/CFS are common in patients with PASC. Dysfunctional breathing, resting hypocapnia, and ME/CFS may contribute to symptoms. CPET is a valuable tool for assessing these patients.
JACC-HEART FAILURE
(2021)
Article
Psychiatry
Inigo Murga et al.
Summary: The study identified five clinical phenotypes in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, including groups with varying levels of anxiety and depression as well as combinations of fibromyalgia with dysautonomia, neuroendocrine, or immune features. Women scored higher in cognition, pain level, and depressive syndrome compared to men.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Medicine, General & Internal
Undine-Sophie Deumer et al.
Summary: ME/CFS is a chronic systemic disease with various complex symptoms and varying severity. There are currently no reliable biomarkers for diagnosis, and the pathogenesis of the disease may be related to infectious, genetic, hormonal factors, gut microbiota, and non-coding RNA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Bettina Hohberger et al.
Summary: COVID-19 clinical features are caused by SARS-CoV-2, acute infection management is a significant healthcare issue, and the development of long-Covid syndrome poses challenges for patients and physicians. LCS is associated with various characteristics, such as impaired capillary microcirculation, chronic fatigue syndrome, proinflammatory cytokines, and functional autoantibodies targeting GPCR-AAbs.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Greg Vanichkachorn et al.
Summary: This study describes the characteristics of patients experiencing prolonged symptoms after COVID-19 infection. Most patients did not require hospitalization, were younger, predominantly female, and did not have preexisting comorbidities. Symptoms such as mood disorders, fatigue, and cognitive impairment significantly affected the functional and occupational activities of these patients.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Medicine, General & Internal
Constantin-Cristian Topriceanu et al.
Summary: The study found that during the COVID-19 pandemic, women and individuals with chronic illnesses were significantly more affected by cancellations of surgical or medical appointments. Ethnic minorities and individuals with chronic illnesses required more care hours during the lockdown. Socioeconomic position was not associated with cancellation or care hours, and age was not independently associated with the outcomes.
Article
Environmental Sciences
Shuhei Nomura et al.
Summary: This paper provides an overview of the background and mission of the Health Emergency and Disaster Risk Management Research Network (HEALTH EDRM RN) established by the World Health Organization and its partners in 2016, and summarizes the recent progress of the network in terms of research activities, collaborative meetings, and workshops.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Lindsay S. Petracek et al.
Summary: COVID-19 infection may trigger ME/CFS in adolescents and young adults. Patients exhibited orthostatic intolerance symptoms early in the illness, and met criteria for ME/CFS after 6 months. Comorbid features like neuromuscular limitations, orthostatic intolerance, allergies, and neurologic abnormalities should be further studied for potential interventions.
FRONTIERS IN MEDICINE
(2021)
Article
Health Care Sciences & Services
Bibi Holge-Hazelton et al.
Summary: During the COVID-19 pandemic, ward managers often faced challenges in terms of lack of information, involvement in decision-making, and acknowledgment from higher-ups, due to existing organizational cultures and traditional communication hierarchies. When balancing the needs of different stakeholders, ward managers' self-confidence and leadership values came under significant pressure.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Health Care Sciences & Services
Hasan Falah Hasan
Summary: This study identified the responses of health systems in Arab countries to COVID-19 and highlighted the legal and health challenges faced during the pandemic. It also found that some Arab countries are managing to control the pandemic through various strategies but are facing barriers and challenges in their health systems. Acceptable healthcare quality, access, workforce, and funds are essential for a sustainable response to the COVID-19 pandemic in Arab countries.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Medicine, General & Internal
Menna A. E. G. Aly et al.
Summary: This study aimed to investigate post-COVID-19 symptoms amongst elderly females and their potential link to developing chronic fatigue syndrome (CFS). Results showed that fatigue, cognitive impairment, stress, sadness, sleep disturbances, and recurrent falls during the post-recovery period were significantly associated with CFS-like symptoms.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Neurosciences
Elisa Mantovani et al.
Summary: The study found that 27% of SARS-CoV-2 survivors exhibit symptoms resembling ME/CFS, with these individuals showing worse sleep quality, fatigue, pain, depressive symptoms, and cognitive complaints. This raises concerns about a potential future pandemic of ME/CFS-like symptoms in SARS-CoV-2 survivors.
JOURNAL OF NEUROVIROLOGY
(2021)
Article
Multidisciplinary Sciences
Bindu D. Paul et al.
Summary: The review summarizes evidence of biological abnormalities in patients with acute COVID-19 and ME/CFS, including redox imbalance, systemic inflammation, neuroinflammation, impaired ATP generation, and general hypometabolism. Although these phenomena have not been extensively studied in individuals with long COVID-19, understanding these abnormalities may lead to the development of novel therapeutics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Multidisciplinary Sciences
Nisreen A. Alwan
Review
Biochemistry & Molecular Biology
Anthony L. Komaroff et al.
Summary: SARS-CoV-2 infection can lead to chronic and acute diseases, with postacute sequelae including potential organ damage and symptoms, as well as a post-COVID19 syndrome called 'long COVID' resembling ME/CFS symptoms.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Economics
D. Araja et al.
Article
Environmental Sciences
Nur Zahirah Balqis-Ali et al.
Summary: This study investigated Malaysia's health system response to COVID-19, identifying various issues across different building blocks of the system and highlighting the importance of leadership and governance. Understanding the complexities and interactions between different building blocks is crucial in strengthening health systems and improving service delivery during disease outbreaks.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Infectious Diseases
Shin Jie Yong
Summary: Long COVID or post-COVID-19 syndrome is a poorly understood condition that affects survivors with symptoms like fatigue, dyspnoea, cognitive impairments, and more. The pathophysiology, risk factors, and treatments are still lacking in literature, but potential treatments may include rehabilitation training and repurposed drugs from similar conditions. Further research is needed to substantiate risk factors and treatment options.
INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Diana Araja et al.
Summary: ME/CFS is a complex disorder with severe fatigue and other symptoms, causing substantial reductions in functional activity and quality of life. The study investigates undiagnosed ME/CFS patients, with a focus on potential post-viral CFS as a consequence of COVID-19. Results show that former COVID-19 patients report more anxiety and fatigue symptoms compared to ME/CFS patients and undiagnosed patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
J. Antonio Gonzalez-Hermosillo et al.
Summary: The study found that fatigue was the most common symptom among COVID-19 recovered adults, with those aged 40 to 50 years being more likely to experience fatigue. Only 13% of patients met the criteria for ME/CFS.
Article
Health Care Sciences & Services
Barbara Plagg et al.
Summary: The COVID-19 pandemic tested the resilience of health systems worldwide, with outcomes impacted by health management choices and underlying healthcare systems. Strengthening primary healthcare, hospital organization, and cooperation between different healthcare providers is crucial in preventing overwhelmed hospitals and protecting patients and healthcare workers during large-scale health emergencies. Further analysis of structural determinants is needed to develop more resilient and integrated healthcare systems.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Primary Health Care
Sari Harenwall et al.
Summary: The Primary Care Wellbeing Service (PCWBS) in Bradford District Care NHS Foundation Trust is providing a 7-week virtual rehabilitation course specifically designed for individuals experiencing long-term effects of COVID-19, led by an interdisciplinary team of health professionals. By adopting a biopsychosocial approach, the course aims to improve patients' health outcomes by addressing issues related to post-viral fatigue (PVF) and providing holistic care and support.
JOURNAL OF PRIMARY CARE AND COMMUNITY HEALTH
(2021)
Article
Medicine, General & Internal
Hannah E. Davis et al.
Summary: Patients with Long COVID report prolonged, multisystem involvement and significant disability. By seven months, many patients have not yet recovered (mainly from systemic and neurological/cognitive symptoms), have not returned to previous levels of work, and continue to experience significant symptom burden.
Article
Medicine, Research & Experimental
Leonard A. Jason et al.
Summary: Symptoms among long-hauler COVID-19 patients tend to decrease over time, with an intensification of neurocognitive symptoms, while compared to ME/CFS, COVID-19 long-haulers initially have more severe symptoms in immune and orthostatic domains but show less severe symptoms over time, except in the orthostatic domain.
FATIGUE-BIOMEDICINE HEALTH AND BEHAVIOR
(2021)
Review
Medicine, General & Internal
Timothy L. Wong et al.
Summary: Early studies on long COVID symptoms show significant overlaps with ME/CFS, highlighting the need for monitoring and treatment. Further research into the similarities and differences between long COVID and ME/CFS is warranted.
MEDICINA-LITHUANIA
(2021)
Review
Infectious Diseases
Sonia Poenaru et al.
Summary: COVID-19 can lead to a prolonged convalescence with chronic symptoms resembling those of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), although more research is needed to confirm any link between the two conditions.
THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE
(2021)
Review
Health Policy & Services
Max Ying Hao Lim et al.
Summary: Current literature lacks a comprehensive conceptualisation of health workforce governance, often borrowing governance concepts from the broader health field without adapting them to the specific context of health workforce. Dimensional analysis of governance largely focuses on operationalising practices rather than expanding on conceptual understanding, with stakeholder participation and strategic direction identified as essential sub-functions. Further research is needed to explore and develop the conceptual thinking behind health workforce governance.
HUMAN RESOURCES FOR HEALTH
(2021)
Editorial Material
Medicine, General & Internal
Zunyou Wu et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Medicine, General & Internal
Giacomo Grasselli et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Medicine, General & Internal
Fei Zhou et al.
Article
Cardiac & Cardiovascular Systems
Shaobo Shi et al.
Review
Cardiac & Cardiovascular Systems
Guoliang Li et al.
CARDIOLOGY JOURNAL
(2020)
Editorial Material
Public, Environmental & Occupational Health
Stephanie M. Topp
Editorial Material
Public, Environmental & Occupational Health
Maryam Bigdeli et al.
Editorial Material
Public, Environmental & Occupational Health
Stephen Thomson et al.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2020)
Editorial Material
Environmental Sciences
Milena Vainieri et al.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Editorial Material
Public, Environmental & Occupational Health
Rajat Khosla et al.
Letter
Cardiac & Cardiovascular Systems
Oliver Robak et al.
CARDIOLOGY JOURNAL
(2020)
Article
Medicine, General & Internal
Janet E. Anderson et al.
Review
Medicine, General & Internal
Jasna Omersel et al.
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Health Care Sciences & Services
Derek F. H. Pheby et al.
Article
Immunology
G. A. Poland et al.
Article
Health Care Sciences & Services
Richard B. Saltman et al.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2016)
Review
Immunology
Jennifer A. Whitaker et al.
EXPERT REVIEW OF VACCINES
(2015)
Article
Immunology
Mark J. Geels et al.
Review
Immunology
Gregory A. Poland et al.
SEMINARS IN IMMUNOLOGY
(2013)
