4.7 Review

Long noncoding RNAs (lncRNAs) in human lymphomas

期刊

GENES & DISEASES
卷 9, 期 4, 页码 900-914

出版社

ELSEVIER
DOI: 10.1016/j.gendis.2021.02.001

关键词

Apoptosis; Long non-coding RNA; Lymphoma; Prognosis; Proliferation

资金

  1. Clinical Research Development Center of Taleghani
  2. mam Ali Hospital, Kermanshah University of Medical Sciences, Iran

向作者/读者索取更多资源

This review summarizes the role of lncRNAs in lymphomas and their potential clinical value. It has been found that lncRNAs play a critical role in lymphoma carcinogenesis by affecting apoptosis, cell proliferation, invasion, and response to chemotherapy.
Lymphomas are a diverse group of haematologic malignancies, which occur in infection-fighting cells of the lymphatic system. Long non-coding RNAs (lncRNAs) are noncoding RNAs, which have recently received significant attention as the main mediators of gene expression. In this review, we summarize the current knowledge on lncRNAs involved in lymphomas, their molecular functions, as well as their potential clinical value. Relevant literature was identified by a PubMed search of English language papers using the following terms: Lymphoma, LncRNA, leukemia, proliferation, apoptosis, and prognosis. LncRNAs are imperative for lymphoma carcinogenesis through affecting apoptosis, cell proliferation, invasion, and response to chemotherapy. The expression level of lncRNAs can affect chemotherapyinduced apoptosis. Taken together, lncRNA dysregulation in lymphoma cells is not only an epiphenomenon but also lncRNA transcription is critically related to the initiation and progression of lymphomas. Aberrant expression of lncRNAs can lead to the transformation of normal lymphocytes into lymphoma cells.Copyright (c) 2021, Chongqing Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/ 4.0/).

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据