An efficient synthesis of pyrimido [4,5-b] quinoline and indenopyrido[2,3-d]pyrimidine derivatives in the presence of Fe3O4 @nano-cellulose/Sb (V) as a bio-based magnetic nano-catalyst

In this study, an eco-friendly approach was introduced to synthetize pyrimido [4,5-b]quinolones and indenopyrido[2,3-d]pyrirnidines. This synthesis was done via three-component coupling of: 6-amino-2-(methylthio) pyrimidin-4(3H)-one, 1,3-indanedione/dimedone, and aromatic aldehydes using Fe3O4@nano-cellulose/Sb (V) as a catalyst under the solvent-free condition at 70 degrees C by electrical mortar-heater. The catalyst was separated from the reaction mixture by an external magnet and reused for subsequent reactions. The present procedure offers many advantages such as high yield, easy work-up, simple isolation of catalyst by external magnet, and high reusability. The structures of the obtained pyrimido[4,5-b]quinolones and indenopyrido[2,3-d]pyrirnidines products were studied by FT-IR, H-1-NMR, and C-13-NMR spectroscopic data. (C) 2022 Sharif University of Technology. All rights reserved.

Automated summary

In this study, an eco-friendly method for synthesizing pyrimido[4,5-b]quinolones and indenopyrido[2,3-d]pyrirnidines was introduced. The synthesis was carried out via a three-component coupling reaction under solvent-free conditions using Fe3O4@nano-cellulose/Sb(V) as a catalyst. The catalyst could be separated by an external magnet and reused for subsequent reactions.