Persistence of airway inflammation in smokers who switch to electronic cigarettes

Article Multidisciplinary Sciences

Smoking cessation reduces systemic inflammation and circulating endothelin-1

Cassandra C. Derella et al.

Summary: The study revealed that a 12-week smoking cessation program can reduce concentrations of ET-1 and TNF-alpha for at least a year. The decrease in serum cotinine is associated with lower levels of circulating ET-1. The reduction in ET-1 and inflammation may contribute to the decreased risk of cardiovascular disease observed with smoking cessation.

SCIENTIFIC REPORTS (2021)

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Review Respiratory System

An updated overview of e-cigarette impact on human health

Patrice Marques et al.

Summary: The electronic cigarette, considered a safe alternative to traditional cigarettes, has revolutionized the tobacco industry. While it may be safer than conventional cigarettes, there are still debates on its safety and effectiveness as a smoking cessation method. Short-term use of e-cigarettes has shown harmful effects, and the long-term impact remains insufficiently understood.

RESPIRATORY RESEARCH (2021)

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Article Respiratory System

Losartan reduces cigarette smoke-induced airway inflammation and mucus hypersecretion

Michael D. Kim et al.

Summary: The study aimed to investigate whether losartan could reduce cigarette smoke-induced airway inflammation and mucus hypersecretion. The results showed that losartan treatment rescued cigarette smoke-induced dysfunction in HBECs and decreased expression of MUC5AC, partially through inhibiting TGF-beta signaling. In a clinical trial, smokers treated with losartan showed reduced levels of MUC5AC, TGF-beta 1, and MMP-9 mRNA in the upper airways after 2 months, suggesting that losartan may be effective in reducing inflammation and mucus hypersecretion in chronic airway diseases induced by cigarette smoke.

ERJ OPEN RESEARCH (2021)

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Article Critical Care Medicine