期刊
ORGANIC CHEMISTRY FRONTIERS
卷 3, 期 5, 页码 561-564出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5qo00421g
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资金
- Pennsylvania State University
- Nankai University
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1055795] Funding Source: National Science Foundation
A new protocol for Pd-catalyzed beta methylene C-H arylation of N-quinolyl cycloalkylcarboxamides with aryl iodides at room temperature is reported. The beta methylene C-H bonds of symmetrical cycloalkylcarboxamides of varied ring size can be arylated in moderate to good yields and monoselectivity with excellent diastereoselectivity. This mono-selective beta methylene C-H arylation reaction enabled the rapid synthesis of complex carbocycle products from easily accessible symmetrical cycloalkyl carboxylic acids via sequential C-H functionalization.
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