期刊
NATURAL PRODUCT REPORTS
卷 39, 期 9, 页码 1766-1802出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1np00077b
关键词
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资金
- National Natural Science Foundation of China [81973438, 82174025]
- NSFC-Joint Foundation of Yunnan Province [U1902213]
- Fok Ying-Tong Education Foundation [161039]
- Guangdong Province Key Area R&D Program of China [2020B1111110003]
Natural products containing a phloroglucinol motif have significant medicinal value and biological activities. Recent studies have focused on synthetic approaches to these compounds, which have been widely used in treatment and clinical trials.
Covering: June 2009 to 2021 Natural products containing a phloroglucinol motif include simple and oligomeric phloroglucinols, polycyclic polyprenylated acylphloroglucinols, phloroglucinol-terpenes, xanthones, flavonoids, and coumarins. These compounds represent a major class of secondary metabolites which exhibit a wide range of biological activities such as antimicrobial, anti-inflammatory, antioxidant and hypoglycaemic properties. A number of these compounds have been authorized for therapeutic use or are currently being studied in clinical trials. Their structural diversity and utility in both traditional and conventional medicine have made them popular synthetic targets over the years. In this review, we compile and summarise the recent synthetic approaches to the natural products bearing a phloroglucinol motif. Focus has been given on ingenious strategies to functionalize the phloroglucinol moiety at multiple positions. The isolation and bioactivities of the compounds are also provided.
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