Silver(I)-promoted C5-H phosphonation of 8-aminoquinoline amides with H-phosphonates

A simple and efficient protocol for silver(I)-promoted phosphonation of 8-aminoquinoline amides with dialkyl H-phosphonates has been developed, affording the desired products in moderate yields. This method features C5-H regioselectivity of 8-aminoquinoline amides, a broad substrate scope and general functional group compatibility.