4.7 Article

Highly enantioselective Pd-catalyzed indole allylic alkylation using binaphthyl-based phosphoramidite-thioether ligands

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ORGANIC CHEMISTRY FRONTIERS
卷 3, 期 10, 页码 1246-1249

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c6qo00227g

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资金

  1. National Natural Science Foundation of China [21272087, 21202053, 21472058, 21472057, 21232003]
  2. Youth Chen-Guang Project of Wuhan [2015070404010180]

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A novel type of binaphthyl-based phosphoramidite-thioether ligand has been developed and successfully applied to Pd-catalysed asymmetric C-3 allylic alkylation of indoles, giving the desired products with up to 99% yield and 98% ee.

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