期刊
WIRES MECHANISMS OF DISEASE
卷 14, 期 6, 页码 -出版社
WILEY
DOI: 10.1002/wsbm.1570
关键词
pain genes; pain genetics; pain genomics
资金
- National Institute of Neurological Disorders and Stroke [R01NS100788, R01NS114018]
This article presents methods for identifying and validating pain-related genes, provides a list of genes associated with pain behavior, and analyzes their expression patterns. It also discusses the potential of forward genetic screening approaches to improve the identification of pain genes.
The development of novel pain therapeutics hinges on the identification and rigorous validation of potential targets. Model organisms provide a means to test the involvement of specific genes and regulatory elements in pain. Here we provide a list of genes linked to pain-associated behaviors. We capitalize on results spanning over three decades to identify a set of 242 genes. They support a remarkable diversity of functions spanning action potential propagation, immune response, GPCR signaling, enzymatic catalysis, nucleic acid regulation, and intercellular signaling. Making use of existing tissue and single-cell high-throughput RNA sequencing datasets, we examine their patterns of expression. For each gene class, we discuss archetypal members, with an emphasis on opportunities for additional experimentation. Finally, we discuss how powerful and increasingly ubiquitous forward genetic screening approaches could be used to improve our ability to identify pain genes. This article is categorized under: Neurological Diseases > Genetics/Genomics/Epigenetics Neurological Diseases > Molecular and Cellular Physiology
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据