Ruthenium(ii)-catalyzed synthesis of CF3-isoquinolinones via C-H activation/annulation of benzoic acids and CF3-imidoyl sulfoxonium ylides

A ruthenium(ii)-catalyzed C-H activation/annulation reaction of benzoic acids and CF3-imidoyl sulfoxonium ylides enabled by weak O-coordination has been achieved. A series of 3-trifluoromethylisoquinolinones were synthesized in 37-75% yields under redox-neutral reaction conditions.

Automated summary

The ruthenium(ii)-catalyzed C-H activation/annulation reaction of benzoic acids and CF3-imidoyl sulfoxonium ylides, enabled by weak O-coordination, has been achieved to synthesize a series of 3-trifluoromethylisoquinolinones in yields ranging from 37% to 75%.