Prokaryotic and eukaryotic toxicity of halloysite decorated with photoactive nanoparticles

The development of new approaches to treat the growing antibiotic resistance of pathogenic bacterial species is an important task to ensure the future safety of society. Utilization of irradiation of different wavelengths together with nanostructured materials based on metal containing nanoparticles may result in synergetic antibacterial effects. In this paper we aim to show the main conceptions of light-assisted bacteria deactivation techniques and prospects of application of natural clay nanotubes as a carrier for scalable photoactive antibacterial nanomaterials. Halloysite aluminosilicate nanotubes (ca 50 nm diameter, ca. 1.0 mu m length) are safe and biocompatible natural materials produced in tons. Their application as a template or a carrier for metal nanoparticles, QDs and organic compounds has already found application in biomedical research, cosmetics, polymers, coatings, catalysis and related applications. Here, we show the toxicity of halloysite decorated with photoactive nanoparticles on prokaryotic and eukaryotic cells. The formation of light active nanostructured materials with this clay as the base is a promising tool for solving the problem of the antibiotic resistance of microorganisms.

Automated summary

The development of new approaches to address antibiotic resistance is crucial for societal safety. This paper explores the concepts of light-assisted bacteria deactivation techniques and the potential use of natural clay nanotubes as carriers for photoactive antibacterial nanomaterials. The study demonstrates the toxicity of halloysite decorated with photoactive nanoparticles on prokaryotic and eukaryotic cells, suggesting the promising application of these nanostructured materials in solving the problem of antibiotic resistance.