期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 86, 期 8, 页码 1095-1105出版社
OXFORD UNIV PRESS
DOI: 10.1093/bbb/zbac082
关键词
sedentary behavior; obesity; abdominal fat; oleamide; inflammation
类别
资金
- Food Science Institute Foundation (Ryoushoku-kenkyukai) [2019A12]
- Japan Society for the Promotion of Science [20K21285]
- Nagaoka Co. Ltd.
The study found that housing mice in small cages leads to obesity and abdominal fat accumulation, but dietary oleamide can suppress this obesity.
Physical inactivity due to prolonged sedentary behavior induces obesity. Therefore, we investigated whether housing mice in small cages to mimic sedentary behavior induced obesity and whether dietary oleamide (cis-9,10-octadeceneamide) suppressed the induced obesity. A single oral administration of oleamide (50 mg/kg) to mice resulted in the accumulation of the exogenous oleamide in abdominal visceral fat. Next, mice were housed in small cages and oleamide (50 mg/kg/d) was orally administered for 12 weeks. Housing mice in small cages impaired glucose tolerance and increased food efficiency. It also increased body weight and abdominal fat mass. Dietary oleamide improved the impairment and inhibited their increase in mice housed in small cages. Furthermore, dietary oleamide suppressed the mRNA expression of inflammation-related factors in the abdominal fat of mice housed in small cages. Hence, these results indicate that although housing mice in small cages induces obesity and increases abdominal fat mass, dietary oleamide suppresses the obesity.
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