期刊
JOURNAL OF THE ENDOCRINE SOCIETY
卷 6, 期 8, 页码 -出版社
ENDOCRINE SOC
DOI: 10.1210/jendso/bvac090
关键词
parathyroid carcinoma; parathyroid autofluorescence; near-infrared autofluorescence
Parathyroid carcinoma is a rare disease and difficult to confirm during surgery. Near-infrared autofluorescence may aid in intraoperative detection of parathyroid carcinoma, but more research is needed.
Introduction: Parathyroid carcinoma is very rare, and intraoperative definitive diagnosis can be elusive with currently available diagnostics. Near-infrared (NIR) autofluorescence is an emerging tool that identifies parathyroid glands in real time. It is not known whether NIR autofluorescence can detect parathyroid carcinoma intraoperatively. Methods: Patients with preoperative suspicion for parathyroid carcinoma were identified from ongoing studies examining parathyroid autofluorescence with a NIR camera and probe. Specimens from these patients were examined intraoperatively to determine their autofluorescence patterns. Results: Three patients with suspected parathyroid carcinoma were identified preoperatively. Intraoperative NIR autofluorescence imaging showed a relative lack of autofluorescence for all cases, in contrast to parathyroid adenomas and normal parathyroid glands, which typically exhibit significant autofluorescence. Final pathology confirmed parathyroid carcinoma in all cases. Conclusion: Parathyroid carcinoma can be difficult to confirm prior to final pathology review. Our 3 cases suggest that absence of NIR autofluorescence may suggest the likelihood of parathyroid carcinoma, but more studies are needed to investigate this experience.
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