期刊
ONCOIMMUNOLOGY
卷 5, 期 8, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2016.1200771
关键词
Cancer; Immunometabolism; MDSC
资金
- NCI NIH HHS [R01 CA184185, R01 CA082689, R01 CA107974] Funding Source: Medline
- NIAID NIH HHS [R01 AI112402] Funding Source: Medline
- NIGMS NIH HHS [P30 GM114732, P20 GM103501] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA184185] Funding Source: NIH RePORTER
MDSC undergo metabolic reprogramming in the tumor resulting in an increased fatty acid beta oxidation that supports their immunosuppressive functions. Fatty acid oxidation inhibitors, used to treat coronary disease, significantly delayed tumor growth and had a significantly increased antitumor effect when combined with adoptive cell therapy or low dose chemotherapy.
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