期刊
CHEMICAL COMMUNICATIONS
卷 58, 期 61, 页码 8512-8515出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc01948e
关键词
-
资金
- National Natural Science Foundation of China [21978241, U1803283, 21878249]
A cell membrane bionic nano delivery system was designed to selectively accumulate in tumors and generate CO upon red light irradiation, significantly improving the therapeutic effect of the chemotherapy drug DOX.
Chemotherapy assisted by carbon monoxide (CO) gas therapy is an emerging powerful cancer therapeutic modality. However, the effective delivery and controlled release of CO in tumor cells remain a challenge. Herein, a cell membrane bionic nano delivery system (RBC-H@DOX/3-HF@MSN, termed as RHM) was designed to selectively accumulate in tumors and generate CO in situ upon red light irradiation for the combination of chemotherapy and gas therapy. CO significantly improves the therapeutic effect of DOX from 29.0% to 82.4%.
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