期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 10, 期 28, 页码 5344-5351出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tb00971d
关键词
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资金
- Jiangsu Higher Education Institutions [19KJA310001]
- Natural Science Foundation of China [81870358, 92068116]
- Science Fund for Distinguished Young Scholars in Jiangsu Province [BK20211501]
- Key Projects of Science and Technology of Jiangsu Province [BE2019602]
- Jiangsu Higher Education Institutions (PAPD)
A new H2S-releasing hydrogel system significantly improved microvascular obstruction, prevented myocardial fibrosis, and attenuated cardiac inflammation in an experimental I/R model of rats. The novel H2S-releasing hydrogel represents a promising therapeutic strategy targeting myocardial ischemia-reperfusion injury.
Myocardial infarction is one of the leading causes of death worldwide. Thus, protection against myocardial ischemia-reperfusion injury is particularly important to improve the prognosis of myocardial infarction. Recently, hydrogen sulfide (H2S) has been reported to possess a protective effect against myocardial ischemia-reperfusion injury. However, an effective gas delivery system to release H2S controllably at an appropriate concentration needs to be further investigated. In this study, a new H2S-releasing hydrogel system was constructed and applied in an experimental I/R model of rats. The administration of the hydrogel significantly ameliorated microvascular obstruction, prevented myocardial fibrosis, and attenuated cardiac inflammation. This suggested that the novel H2S-releasing hydrogel represented a promising therapeutic strategy targeting myocardial ischemia-reperfusion injury.
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